FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. FoxO1 controls the transcription of downstream genes mediating metabolic regulation. Dysfunction of FoxO1 pathways results in several metabolic diseases, including diabetes, obesity, non-alcoholic fatty liver disease, and atherosclerosis. Here, we summarize the mechanism of FoxO1 regulation behind these diseases and FoxO1-related drug discoveries.

A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries

Shiming Peng 1, Wei Li 2, Nannan Hou 1 and Niu Huang 1,3,*

1 National Institute of Biological Sciences, Beijing 102206, China

2 RPXDs (Suzhou) Co., Ltd., Suzhou 215123, China

3 Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China