{"id":483,"date":"2014-10-24T10:48:33","date_gmt":"2014-10-24T02:48:33","guid":{"rendered":"http:\/\/www.huanglab.org.cn\/wordpress\/?p=483"},"modified":"2014-10-26T10:51:30","modified_gmt":"2014-10-26T02:51:30","slug":"2014%e5%b9%b410%e6%9c%8813%e6%97%a5%ef%bc%8cnibs%e9%82%b5%e5%b3%b0%e5%ae%9e%e9%aa%8c%e5%ae%a4%e5%9c%a8%e3%80%8aelife%e3%80%8b%e6%9d%82%e5%bf%97%e5%9c%a8%e7%ba%bf%e5%8f%91%e8%a1%a8a-structural","status":"publish","type":"post","link":"https:\/\/www.huanglab.org.cn\/wordpress\/?p=483","title":{"rendered":"2014\u5e7410\u670813\u65e5\uff0cNIBS\u90b5\u5cf0\u5b9e\u9a8c\u5ba4\u5728\u300aeLife\u300b\u6742\u5fd7\u5728\u7ebf\u53d1\u8868\u201cA structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family\u201d\u7684\u7814\u7a76\u8bba\u6587.\uff0d\uff0d\u9ec4\u725b\u5b9e\u9a8c\u5ba4\u4e07\u5c0f\u6ce2\u535a\u58eb\u5bf9\u672c\u6587\u6709\u91cd\u8981\u8d21\u732e"},"content":{"rendered":"<p>2014\u5e7410\u670813\u65e5\uff0cNIBS\u90b5\u5cf0\u5b9e\u9a8c\u5ba4\u5728\u300aeLife\u300b\u6742\u5fd7\u5728\u7ebf\u53d1\u8868\u201cA structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family\u201d\u7684\u7814\u7a76\u8bba\u6587\uff08http:\/\/elifesciences.org\/content\/early\/2014\/10\/13\/eLife.03714\uff09\u3002\u8be5\u7814\u7a76\u62a5\u9053\u4e86\u4e00\u4e2a\u6765\u81ea\u4e8e\u9769\u5170\u6c0f\u9634\u6027\u83cc\u7684\u4e03\u78b3\u7cd6\u7cd6\u57fa\u8f6c\u79fb\u9176\u5bb6\u65cf\u6210\u5458TibC\u768412\u805a\u4f53\u7684\u6676\u4f53\u7ed3\u6784\u4ee5\u53caTibC\u4e0e\u5e95\u7269TibA\u81ea\u8f6c\u8fd0\u86cb\u767d\u768418\u805a\u4f53\u590d\u5408\u7269\u7684\u51b7\u51bb\u7535\u955c\u91cd\u6784\u6a21\u578b\u3002<\/p>\n<p>\u90b5\u5cf0\u5b9e\u9a8c\u5ba4\u5728\u4e00\u4e2a\u6708\u524d\u521a\u521a\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\u5de5\u4f5c\u4e2d\uff0c\u53d1\u73b0\u548c\u5b9a\u4e49\u4e86\u4e00\u7c7b\u5e7f\u6cdb\u5b58\u5728\u4e8e\u9769\u5170\u6c0f\u9634\u6027\u81f4\u75c5\u83cc\u4e2d\u7684\u65b0\u578b\u4e03\u78b3\u7cd6\u7cd6\u57fa\u8f6c\u79fb\u9176\uff08BAHT\uff09\u5bb6\u65cf\uff0c\u5b83\u4eec\u9ad8\u6548\u50ac\u5316\u7ec6\u83cc\u7c98\u9644\u7d20AIDA-I\u548cTibA\u8868\u9762\u591a\u4f4d\u70b9\u7684\u7cd6\u57fa\u5316\u4fee\u9970\uff0c\u4ece\u800c\u5b9e\u73b0\u7ec6\u83cc\u5bf9\u5bbf\u4e3b\u7ec6\u80de\u7684\u7c98\u9644\u548c\u5728\u5c0f\u9f20\u80a0\u9053\u4e2d\u7684\u6709\u6548\u5b9a\u6b96\uff08Cell Host &amp; Microbe 16: 351-363, 2014\uff09\u3002\u6709\u8da3\u7684\u662f\uff0cBAHT\u5bb6\u65cf\u548c\u5df2\u77e5\u7684\u7cd6\u57fa\u8f6c\u79fb\u9176\u6ca1\u6709\u5e8f\u5217\u4e0a\u7684\u540c\u6e90\u6027\uff0c\u5e76\u4e14\u6240\u6709BAHT\u5bb6\u65cf\u86cb\u767d\u90fd\u7ed3\u5408\u94c1\uff0c\u5f62\u6210\u5927\u7ea6550 kD\u5927\u5c0f\u7684\u9ec4\u8910\u8272\u540c\u6e90\u5341\u4e8c\u805a\u4f53\u3002BAHT\u5bb6\u65cf\u7684\u72ec\u7279\u751f\u5316\u6027\u8d28\u548c\u5df2\u77e5\u7684\u7cd6\u57fa\u8f6c\u79fb\u9176\u7684\u90fd\u4e0d\u540c\uff0c\u4f46\u5176\u50ac\u5316\u548c\u5e95\u7269\u8bc6\u522b\u673a\u7406\u672a\u77e5\u3002<\/p>\n<p>\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u4e3a\u4e86\u63ed\u793aBAHT\u5bb6\u65cf\u7684\u50ac\u5316\u673a\u7406\uff0c\u90b5\u5cf0\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u4eba\u5458\u6210\u529f\u7ed3\u6676\u4e86TibC\u86cb\u767d\u3002\u6676\u4f53\u7ed3\u6784\u7684\u89e3\u6790\u53d1\u73b0TibC\u5355\u4f53\u5206\u5b50\u53ef\u4ee5\u5206\u6210N\u7aef\u03b2\u6298\u53e0\u6876\u7ed3\u6784\u57df\u548cC\u7aef\u50ac\u5316\u6838\u5fc3\u7ed3\u6784\u57df\u300212\u4e2aTibC\u5355\u4f53\u5206\u5b50\u901a\u8fc7\u201c\u624b\u62c9\u624b\u201d\u548c\u201c\u80cc\u9760\u80cc\u201d\u4e24\u79cd\u65b9\u5f0f\u805a\u5408\u6210\u4e00\u79cd\u65b0\u9896\u7684\u82b1\u73af\u72b6\u768412\u805a\u4f53\u7ed3\u6784\uff1b\u8be512\u805a\u4f53\u590d\u5408\u7269\u4e2d\u95f4\u5f62\u6210\u4e00\u4e2a\u5f88\u5927\u7684\u5706\u67f1\u4f53\u901a\u9053\uff0c\u6240\u6709\u5206\u5b50\u7684\u50ac\u5316\u6d3b\u6027\u4e2d\u5fc3\u90fd\u9762\u5411\u8fd9\u4e2a\u901a\u9053\u5185\u90e8\uff0c\u63d0\u793a\u5e95\u7269\u7684\u7cd6\u57fa\u5316\u8fc7\u7a0b\u53ef\u80fd\u662f\u901a\u8fc7\u5e95\u7269\u7a7f\u8fc7\u8fd9\u4e2a\u901a\u9053\u6765\u5b9e\u73b0\u7684\u3002<\/p>\n<p>\u5c3d\u7ba1\u7f3a\u4e4f\u5e8f\u5217\u4e0a\u7684\u540c\u6e90\u6027\uff0cTibC\u5206\u5b50\u7684\u50ac\u5316\u7ed3\u6784\u57df\u4e0e\u7cd6\u57fa\u8f6c\u79fb\u9176\u5bb6\u65cf\u4e2dGT-B\u6298\u53e0\u7c7b\u4f3c\u3002\u6b64\u5916\uff0cTibC\u50ac\u5316\u7ed3\u6784\u57df\u542b\u6709\u03b2\u53d1\u5939\u62c7\u6307\u7ed3\u6784\u57fa\u5143\u548c\u94c1\u6307\u7ed3\u6784\u57fa\u5143\u3002\u57fa\u4e8e\u7ed3\u6784\u7684\u751f\u5316\u5b9e\u9a8c\u8bc1\u660e\uff0c\u8fd9\u4e24\u4e2a\u72ec\u7279\u7684\u7ed3\u6784\u57fa\u5143\u5728TibC\u5341\u4e8c\u805a\u4f53\u7684\u6b63\u786e\u7ec4\u88c5\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u3002\u7814\u7a76\u4eba\u5458\u8fd8\u8fdb\u4e00\u6b65\u6210\u529f\u5c06ADP-D,D-\u4e03\u78b3\u7cd6\u4f5c\u4e3a\u914d\u4f53\u52a0\u5165TibC\u6676\u4f53\u4e2d\u5e76\u89e3\u6790\u4e86\u9176\u548c\u914d\u4f53\u7684\u7ed3\u6784\u3002\u901a\u8fc7\u5bf9\u8be5\u914d\u4f53\u590d\u5408\u7269\u7ed3\u6784\u7684\u5206\u6790\u4e0d\u4ec5\u63ed\u793a\u4e86\u53c2\u4e0e\u7cd6\u57fa\u8f6c\u79fb\u7684\u5173\u952e\u6b8b\u57fa\u548c\u50ac\u5316\u673a\u7406\uff0c\u800c\u4e14\u8fd8\u9610\u660e\u4e86BATH\u5bb6\u65cf\u4e0d\u540c\u6210\u5458\u5bf9\u914d\u4f53\u7acb\u4f53\u6784\u578b\u9009\u62e9\u6027\u7684\u7ed3\u6784\u539f\u7406\u3002<\/p>\n<p>\u5728\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u53d1\u73b0\u5f53\u5e95\u7269TibA\u4e0eTibC\u7a81\u53d8\u4f53K230A \u5728\u5927\u80a0\u6746\u83cc\u4e2d\u5171\u8868\u8fbe\u65f6\uff0c\u80fd\u5f62\u6210\u7a33\u5b9a\u7684750 kD\u5927\u5c0f\u7684\u9176\u4e0e\u5e95\u7269\u7684\u590d\u5408\u7269\u3002\u901a\u8fc7\u7528\u51b7\u51bb\u7535\u955c\u5bf9\u7eaf\u5316\u7684TibC-TibA\u590d\u5408\u7269\u7ed3\u6784\u8fdb\u884c\u4e09\u7ef4\u91cd\u6784\uff0c\u5f97\u5230\u4e86TibC 12\u805a\u4f53\u548cTibA 6\u805a\u4f53\u7ec4\u6210\u7684\u590d\u5408\u7269\u7ed3\u6784\u6a21\u578b\u3002\u5728\u8be5\u590d\u5408\u7269\u4e2d\uff0cTibC\u901a\u8fc7\u94c1\u6307\u7ed3\u6784\u4ee52:1\u7684\u5206\u5b50\u6bd4\u4f8b\u7ed3\u5408TibA\uff0c\u4f7f6\u4e2aTibA\u5206\u5b50\u9576\u5d4c\u5728TibC 12\u805a\u4f53\u5f62\u6210\u7684\u901a\u9053\u4e4b\u4e2d\u3002\u8fd9\u8bf4\u660e\u4e00\u4e2aTibC 12\u805a\u4f53\u5206\u5b50\u80fd\u540c\u65f6\u5bf96\u4e2aTibA\u5206\u5b50\u8fdb\u884c\u7cd6\u57fa\u5316\u4fee\u9970\uff0c\u5c55\u793a\u4e86TibC\u5bf9\u5e95\u7269\u50ac\u5316\u7684\u9ad8\u6548\u6027\u548c\u7ed3\u6784\u5229\u7528\u7684\u7ecf\u6d4e\u6027\u3002<\/p>\n<p>\u672c\u6587\u9996\u6b21\u89e3\u6790\u4e86\u4e00\u4e2a\u65b0\u9896\u7684\u7cd6\u57fa\u8f6c\u79fb\u9176\u4ee5\u53ca\u5176\u548c\u914d\u4f53\u3001\u5e95\u7269\u590d\u5408\u7269\u7684\u7ed3\u6784\u3002\u5e76\u4e14\u63ed\u793aBAHT\u5bb6\u65cf\u7cd6\u57fa\u8f6c\u79fb\u9176\u8bc6\u522b\u5e95\u7269\u548c\u50ac\u5316\u7684\u5206\u5b50\u673a\u5236\u548c\u4f5c\u7528\u65b9\u5f0f\u3002\u300aCell Host &amp; Microbe\u300b\u76f8\u5173\u8bba\u6587\u548c\u672c\u6587\u7684\u5148\u540e\u53d1\u8868\uff0c\u4ece\u9057\u4f20\u3001\u751f\u7406\u673a\u80fd\u3001\u751f\u5316\u6027\u8d28\u3001\u7ed3\u6784\u548c\u529f\u80fd\u7684\u89d2\u5ea6\u5b8c\u6574\u5730\u5b9a\u4e49\u548c\u89e3\u6790\u4e86BAHT\u8fd9\u7c7b\u65b0\u578b\u7684\u75c5\u539f\u83cc\u4e03\u78b3\u7cd6\u7cd6\u57fa\u8f6c\u79fb\u9176\u5bb6\u65cf\u86cb\u767d\u3002\u8be5\u7814\u7a76\u7ed3\u679c\u4e0d\u4ec5\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5e7f\u9614\u7684\u89c6\u89d2\u6765\u52a0\u6df1\u5bf9\u7cd6\u57fa\u8f6c\u79fb\u9176\u548c\u7cd6\u57fa\u5316\u8fc7\u7a0b\u7684\u7406\u89e3\uff0c\u800c\u4e14\u4e5f\u540c\u65f6\u4e3a\u5c06\u6765\u4ee3\u66ff\u6297\u751f\u7d20\u6cbb\u7597\u7ec6\u83cc\u611f\u67d3\u63d0\u4f9b\u4e86\u7406\u8bba\u6307\u5bfc\u3002<\/p>\n<p>\u90b5\u5cf0\u5b9e\u9a8c\u5ba4\u59da\u5e86\u535a\u58eb\u548c\u9646\u79cb\u9e64\u535a\u58eb\u4e3a\u672c\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff1b\u9ec4\u725b\u5b9e\u9a8c\u5ba4\u4e07\u5c0f\u6ce2\u535a\u58eb\u548c\u4e2d\u79d1\u9662\u751f\u7269\u7269\u7406\u6240\u6731\u5e73\u5b9e\u9a8c\u5ba4\u5b8b\u5cf0\u535a\u58eb\u5bf9\u672c\u6587\u4e5f\u6709\u91cd\u8981\u8d21\u732e\uff1b\u8be5\u8bba\u6587\u7684\u5176\u4ed6\u4f5c\u8005\u8fd8\u5305\u62ec\u90b5\u5cf0\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u7814\u7a76\u751f\u8bb8\u60a6\u3001\u5317\u4eac\u5927\u5b66\u5218\u5c0f\u4e91\u6559\u6388\u53ca\u5176\u7814\u7a76\u751f\u80e1\u58a8\u3001\u5965\u5730\u5229\u7ef4\u4e5f\u7eb3\u81ea\u7136\u8d44\u6e90\u4e0e\u751f\u547d\u79d1\u5b66\u5927\u5b66\u7684Alla Zamyatina\u6559\u6388\u4ee5\u53ca\u9ec4\u725b\u535a\u58eb\uff1b\u4e2d\u79d1\u9662\u751f\u7269\u7269\u7406\u6240\u6731\u5e73\u7814\u7a76\u5458\u548c\u90b5\u5cf0\u535a\u58eb\u4e3a\u672c\u6587\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/p>\n<p>\u6b64\u9879\u7814\u7a76\u8fd8\u5f97\u5230\u4e86\u56fd\u5bb6\u8d85\u7ea7\u8ba1\u7b97\u5929\u6d25\u4e2d\u5fc3\u7684\u9f0e\u529b\u652f\u6301\uff0c\u5728\u66fe\u7ecf\u4e16\u754c\u6392\u540d\u7b2c\u4e00\u7684\u5929\u6cb3\u4e00\u53f7\u8ba1\u7b97\u673a\u7cfb\u7edf\u4e0a\uff0c\u540c\u65f6\u4f7f\u7528\u51e0\u767e\u4e43\u81f3\u4e0a\u5343CPU\u6838\u8fdb\u884c\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u8ba1\u7b97\uff0c\u5728\u8f83\u77ed\u7684\u65f6\u95f4\u5185\u80fd\u591f\u5b8c\u6210\u4e86\u4e3b\u8981\u8ba1\u7b97\u5de5\u4f5c\u3002<\/p>\n<p><a href=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2014\/10\/DF9FED6296EB7D3CCE4D4762E69911A7.jpg\"><img loading=\"lazy\" class=\"size-medium wp-image-485 aligncenter\" alt=\"\u56fd\u5bb6\u8d85\u7ea7\u8ba1\u7b97\u5929\u6d25\u4e2d\u5fc3\" src=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2014\/10\/DF9FED6296EB7D3CCE4D4762E69911A7-300x229.jpg\" width=\"300\" height=\"229\" srcset=\"https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2014\/10\/DF9FED6296EB7D3CCE4D4762E69911A7-300x229.jpg 300w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2014\/10\/DF9FED6296EB7D3CCE4D4762E69911A7.jpg 500w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u8be5\u7814\u7a76\u7531\u79d1\u6280\u90e8973\u9879\u76ee\uff0c\u5317\u4eac\u5e02\u653f\u5e9c\uff0c\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u59d4\u5458\u4f1a\uff0c\u4e2d\u79d1\u9662\u5148\u5bfc\u8ba1\u5212\u4ee5\u53ca\u7f8e\u56fdHHMI\u8d44\u52a9\uff0c\u5728\u5317\u4eac\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u5b8c\u6210\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2014\u5e7410\u670813\u65e5\uff0cNIBS\u90b5\u5cf0\u5b9e\u9a8c\u5ba4\u5728\u300aeLife\u300b\u6742\u5fd7\u5728\u7ebf\u53d1\u8868\u201cA structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family\u201d\u7684\u7814\u7a76\u8bba\u6587\uff08http:\/\/elifesciences.org\/content\/early\/2014\/10\/13\/eLife.03714\uff09\u3002\u8be5\u7814\u7a76\u62a5\u9053\u4e86\u4e00\u4e2a\u6765\u81ea\u4e8e\u9769\u5170\u6c0f\u9634\u6027\u83cc\u7684\u4e03\u78b3\u7cd6\u7cd6\u57fa\u8f6c\u79fb\u9176\u5bb6\u65cf\u6210\u5458TibC\u768412\u805a\u4f53\u7684\u6676\u4f53\u7ed3\u6784\u4ee5\u53caTibC\u4e0e\u5e95\u7269TibA\u81ea\u8f6c\u8fd0\u86cb\u767d\u768418\u805a\u4f53\u590d\u5408\u7269\u7684\u51b7\u51bb\u7535\u955c\u91cd\u6784\u6a21\u578b\u3002 \u90b5\u5cf0\u5b9e\u9a8c\u5ba4\u5728\u4e00\u4e2a\u6708\u524d\u521a\u521a\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\u5de5\u4f5c\u4e2d\uff0c\u53d1\u73b0\u548c\u5b9a\u4e49\u4e86\u4e00\u7c7b\u5e7f\u6cdb\u5b58\u5728\u4e8e\u9769\u5170\u6c0f\u9634\u6027\u81f4\u75c5\u83cc\u4e2d\u7684\u65b0\u578b\u4e03\u78b3\u7cd6\u7cd6\u57fa\u8f6c\u79fb\u9176\uff08BAHT\uff09\u5bb6\u65cf\uff0c\u5b83\u4eec\u9ad8\u6548\u50ac\u5316\u7ec6\u83cc\u7c98\u9644\u7d20AIDA-I\u548cTibA\u8868\u9762\u591a\u4f4d\u70b9\u7684\u7cd6\u57fa\u5316\u4fee\u9970\uff0c\u4ece\u800c\u5b9e\u73b0\u7ec6\u83cc\u5bf9\u5bbf\u4e3b\u7ec6\u80de\u7684\u7c98\u9644\u548c\u5728\u5c0f\u9f20\u80a0\u9053\u4e2d\u7684\u6709\u6548\u5b9a\u6b96\uff08Cell Host &amp; Microbe 16: 351-363, 2014\uff09\u3002\u6709\u8da3\u7684\u662f\uff0cBAHT\u5bb6\u65cf\u548c\u5df2\u77e5\u7684\u7cd6\u57fa\u8f6c\u79fb\u9176\u6ca1\u6709\u5e8f\u5217\u4e0a\u7684\u540c\u6e90\u6027\uff0c\u5e76\u4e14\u6240\u6709BAHT\u5bb6\u65cf\u86cb\u767d\u90fd\u7ed3\u5408\u94c1\uff0c\u5f62\u6210\u5927\u7ea6550 kD\u5927\u5c0f\u7684\u9ec4\u8910\u8272\u540c\u6e90\u5341\u4e8c\u805a\u4f53\u3002BAHT\u5bb6\u65cf\u7684\u72ec\u7279\u751f\u5316\u6027\u8d28\u548c\u5df2\u77e5\u7684\u7cd6\u57fa\u8f6c\u79fb\u9176\u7684\u90fd\u4e0d\u540c\uff0c\u4f46\u5176\u50ac\u5316\u548c\u5e95\u7269\u8bc6\u522b\u673a\u7406\u672a\u77e5\u3002 \u5728\u672c\u7814\u7a76\u4e2d\uff0c\u4e3a\u4e86\u63ed\u793aBAHT\u5bb6\u65cf\u7684\u50ac\u5316\u673a\u7406\uff0c\u90b5\u5cf0\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u4eba\u5458\u6210\u529f\u7ed3\u6676\u4e86TibC\u86cb\u767d\u3002\u6676\u4f53\u7ed3\u6784\u7684\u89e3\u6790\u53d1\u73b0TibC\u5355\u4f53\u5206\u5b50\u53ef\u4ee5\u5206\u6210N\u7aef\u03b2\u6298\u53e0\u6876\u7ed3\u6784\u57df\u548cC\u7aef\u50ac\u5316\u6838\u5fc3\u7ed3\u6784\u57df\u300212\u4e2aTibC\u5355\u4f53\u5206\u5b50\u901a\u8fc7\u201c\u624b\u62c9\u624b\u201d\u548c\u201c\u80cc\u9760\u80cc\u201d\u4e24\u79cd\u65b9\u5f0f\u805a\u5408\u6210\u4e00\u79cd\u65b0\u9896\u7684\u82b1\u73af\u72b6\u768412\u805a\u4f53\u7ed3\u6784\uff1b\u8be512\u805a\u4f53\u590d\u5408\u7269\u4e2d\u95f4\u5f62\u6210\u4e00\u4e2a\u5f88\u5927\u7684\u5706\u67f1\u4f53\u901a\u9053\uff0c\u6240\u6709\u5206\u5b50\u7684\u50ac\u5316\u6d3b\u6027\u4e2d\u5fc3\u90fd\u9762\u5411\u8fd9\u4e2a\u901a\u9053\u5185\u90e8\uff0c\u63d0\u793a\u5e95\u7269\u7684\u7cd6\u57fa\u5316\u8fc7\u7a0b\u53ef\u80fd\u662f\u901a\u8fc7\u5e95\u7269\u7a7f\u8fc7\u8fd9\u4e2a\u901a\u9053\u6765\u5b9e\u73b0\u7684\u3002 \u5c3d\u7ba1\u7f3a\u4e4f\u5e8f\u5217\u4e0a\u7684\u540c\u6e90\u6027\uff0cTibC\u5206\u5b50\u7684\u50ac\u5316\u7ed3\u6784\u57df\u4e0e\u7cd6\u57fa\u8f6c\u79fb\u9176\u5bb6\u65cf\u4e2dGT-B\u6298\u53e0\u7c7b\u4f3c\u3002\u6b64\u5916\uff0cTibC\u50ac\u5316\u7ed3\u6784\u57df\u542b\u6709\u03b2\u53d1\u5939\u62c7\u6307\u7ed3\u6784\u57fa\u5143\u548c\u94c1\u6307\u7ed3\u6784\u57fa\u5143\u3002\u57fa\u4e8e\u7ed3\u6784\u7684\u751f\u5316\u5b9e\u9a8c\u8bc1\u660e\uff0c\u8fd9\u4e24\u4e2a\u72ec\u7279\u7684\u7ed3\u6784\u57fa\u5143\u5728TibC\u5341\u4e8c\u805a\u4f53\u7684\u6b63\u786e\u7ec4\u88c5\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u3002\u7814\u7a76\u4eba\u5458\u8fd8\u8fdb\u4e00\u6b65\u6210\u529f\u5c06ADP-D,D-\u4e03\u78b3\u7cd6\u4f5c\u4e3a\u914d\u4f53\u52a0\u5165TibC\u6676\u4f53\u4e2d\u5e76\u89e3\u6790\u4e86\u9176\u548c\u914d\u4f53\u7684\u7ed3\u6784\u3002\u901a\u8fc7\u5bf9\u8be5\u914d\u4f53\u590d\u5408\u7269\u7ed3\u6784\u7684\u5206\u6790\u4e0d\u4ec5\u63ed\u793a\u4e86\u53c2\u4e0e\u7cd6\u57fa\u8f6c\u79fb\u7684\u5173\u952e\u6b8b\u57fa\u548c\u50ac\u5316\u673a\u7406\uff0c\u800c\u4e14\u8fd8\u9610\u660e\u4e86BATH\u5bb6\u65cf\u4e0d\u540c\u6210\u5458\u5bf9\u914d\u4f53\u7acb\u4f53\u6784\u578b\u9009\u62e9\u6027\u7684\u7ed3\u6784\u539f\u7406\u3002 \u5728\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u53d1\u73b0\u5f53\u5e95\u7269TibA\u4e0eTibC\u7a81\u53d8\u4f53K230A \u5728\u5927\u80a0\u6746\u83cc\u4e2d\u5171\u8868\u8fbe\u65f6\uff0c\u80fd\u5f62\u6210\u7a33\u5b9a\u7684750 kD\u5927\u5c0f\u7684\u9176\u4e0e\u5e95\u7269\u7684\u590d\u5408\u7269\u3002\u901a\u8fc7\u7528\u51b7\u51bb\u7535\u955c\u5bf9\u7eaf\u5316\u7684TibC-TibA\u590d\u5408\u7269\u7ed3\u6784\u8fdb\u884c\u4e09\u7ef4\u91cd\u6784\uff0c\u5f97\u5230\u4e86TibC 12\u805a\u4f53\u548cTibA 6\u805a\u4f53\u7ec4\u6210\u7684\u590d\u5408\u7269\u7ed3\u6784\u6a21\u578b\u3002\u5728\u8be5\u590d\u5408\u7269\u4e2d\uff0cTibC\u901a\u8fc7\u94c1\u6307\u7ed3\u6784\u4ee52:1\u7684\u5206\u5b50\u6bd4\u4f8b\u7ed3\u5408TibA\uff0c\u4f7f6\u4e2aTibA\u5206\u5b50\u9576\u5d4c\u5728TibC 12\u805a\u4f53\u5f62\u6210\u7684\u901a\u9053\u4e4b\u4e2d\u3002\u8fd9\u8bf4\u660e\u4e00\u4e2aTibC 12\u805a\u4f53\u5206\u5b50\u80fd\u540c\u65f6\u5bf96\u4e2aTibA\u5206\u5b50\u8fdb\u884c\u7cd6\u57fa\u5316\u4fee\u9970\uff0c\u5c55\u793a\u4e86TibC\u5bf9\u5e95\u7269\u50ac\u5316\u7684\u9ad8\u6548\u6027\u548c\u7ed3\u6784\u5229\u7528\u7684\u7ecf\u6d4e\u6027\u3002 \u672c\u6587\u9996\u6b21\u89e3\u6790\u4e86\u4e00\u4e2a\u65b0\u9896\u7684\u7cd6\u57fa\u8f6c\u79fb\u9176\u4ee5\u53ca\u5176\u548c\u914d\u4f53\u3001\u5e95\u7269\u590d\u5408\u7269\u7684\u7ed3\u6784\u3002\u5e76\u4e14\u63ed\u793aBAHT\u5bb6\u65cf\u7cd6\u57fa\u8f6c\u79fb\u9176\u8bc6\u522b\u5e95\u7269\u548c\u50ac\u5316\u7684\u5206\u5b50\u673a\u5236\u548c\u4f5c\u7528\u65b9\u5f0f\u3002\u300aCell Host &amp; Microbe\u300b\u76f8\u5173\u8bba\u6587\u548c\u672c\u6587\u7684\u5148\u540e\u53d1\u8868\uff0c\u4ece\u9057\u4f20\u3001\u751f\u7406\u673a\u80fd\u3001\u751f\u5316\u6027\u8d28\u3001\u7ed3\u6784\u548c\u529f\u80fd\u7684\u89d2\u5ea6\u5b8c\u6574\u5730\u5b9a\u4e49\u548c\u89e3\u6790\u4e86BAHT\u8fd9\u7c7b\u65b0\u578b\u7684\u75c5\u539f\u83cc\u4e03\u78b3\u7cd6\u7cd6\u57fa\u8f6c\u79fb\u9176\u5bb6\u65cf\u86cb\u767d\u3002\u8be5\u7814\u7a76\u7ed3\u679c\u4e0d\u4ec5\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5e7f\u9614\u7684\u89c6\u89d2\u6765\u52a0\u6df1\u5bf9\u7cd6\u57fa\u8f6c\u79fb\u9176\u548c\u7cd6\u57fa\u5316\u8fc7\u7a0b\u7684\u7406\u89e3\uff0c\u800c\u4e14\u4e5f\u540c\u65f6\u4e3a\u5c06\u6765\u4ee3\u66ff\u6297\u751f\u7d20\u6cbb\u7597\u7ec6\u83cc\u611f\u67d3\u63d0\u4f9b\u4e86\u7406\u8bba\u6307\u5bfc\u3002 \u90b5\u5cf0\u5b9e\u9a8c\u5ba4\u59da\u5e86\u535a\u58eb\u548c\u9646\u79cb\u9e64\u535a\u58eb\u4e3a\u672c\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff1b\u9ec4\u725b\u5b9e\u9a8c\u5ba4\u4e07\u5c0f\u6ce2\u535a\u58eb\u548c\u4e2d\u79d1\u9662\u751f\u7269\u7269\u7406\u6240\u6731\u5e73\u5b9e\u9a8c\u5ba4\u5b8b\u5cf0\u535a\u58eb\u5bf9\u672c\u6587\u4e5f\u6709\u91cd\u8981\u8d21\u732e\uff1b\u8be5\u8bba\u6587\u7684\u5176\u4ed6\u4f5c\u8005\u8fd8\u5305\u62ec\u90b5\u5cf0\u5b9e\u9a8c\u5ba4\u7684\u535a\u58eb\u7814\u7a76\u751f\u8bb8\u60a6\u3001\u5317\u4eac\u5927\u5b66\u5218\u5c0f\u4e91\u6559\u6388\u53ca\u5176\u7814\u7a76\u751f\u80e1\u58a8\u3001\u5965\u5730\u5229\u7ef4\u4e5f\u7eb3\u81ea\u7136\u8d44\u6e90\u4e0e\u751f\u547d\u79d1\u5b66\u5927\u5b66\u7684Alla Zamyatina\u6559\u6388\u4ee5\u53ca\u9ec4\u725b\u535a\u58eb\uff1b\u4e2d\u79d1\u9662\u751f\u7269\u7269\u7406\u6240\u6731\u5e73\u7814\u7a76\u5458\u548c\u90b5\u5cf0\u535a\u58eb\u4e3a\u672c\u6587\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002 \u6b64\u9879\u7814\u7a76\u8fd8\u5f97\u5230\u4e86\u56fd\u5bb6\u8d85\u7ea7\u8ba1\u7b97\u5929\u6d25\u4e2d\u5fc3\u7684\u9f0e\u529b\u652f\u6301\uff0c\u5728\u66fe\u7ecf\u4e16\u754c\u6392\u540d\u7b2c\u4e00\u7684\u5929\u6cb3\u4e00\u53f7\u8ba1\u7b97\u673a\u7cfb\u7edf\u4e0a\uff0c\u540c\u65f6\u4f7f\u7528\u51e0\u767e\u4e43\u81f3\u4e0a\u5343CPU\u6838\u8fdb\u884c\u5206\u5b50\u52a8\u529b\u5b66\u6a21\u62df\u8ba1\u7b97\uff0c\u5728\u8f83\u77ed\u7684\u65f6\u95f4\u5185\u80fd\u591f\u5b8c\u6210\u4e86\u4e3b\u8981\u8ba1\u7b97\u5de5\u4f5c\u3002 \u8be5\u7814\u7a76\u7531\u79d1\u6280\u90e8973\u9879\u76ee\uff0c\u5317\u4eac\u5e02\u653f\u5e9c\uff0c\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u59d4\u5458\u4f1a\uff0c\u4e2d\u79d1\u9662\u5148\u5bfc\u8ba1\u5212\u4ee5\u53ca\u7f8e\u56fdHHMI\u8d44\u52a9\uff0c\u5728\u5317\u4eac\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u5b8c\u6210\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0},"categories":[],"tags":[],"_links":{"self":[{"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/483"}],"collection":[{"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=483"}],"version-history":[{"count":6,"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/483\/revisions"}],"predecessor-version":[{"id":491,"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/483\/revisions\/491"}],"wp:attachment":[{"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}