{"id":1330,"date":"2024-05-08T11:15:41","date_gmt":"2024-05-08T03:15:41","guid":{"rendered":"https:\/\/www.huanglab.org.cn\/wordpress\/?p=1330"},"modified":"2024-05-08T11:16:55","modified_gmt":"2024-05-08T03:16:55","slug":"hlife-article-%e9%9d%9e%e5%b8%b8%e4%b9%8b%e8%a7%82%ef%bc%8c%e5%b8%b8%e5%9c%a8%e4%ba%8e%e9%99%a9%e8%bf%9c%ef%bc%9a%e6%8e%a2%e7%b4%a2gpcr%e5%88%ab%e6%9e%84%e4%bd%8d%e7%82%b9%e7%9a%84%e8%99%9a%e6%8b%9f","status":"publish","type":"post","link":"https:\/\/www.huanglab.org.cn\/wordpress\/?p=1330","title":{"rendered":"hLife Article | \u975e\u5e38\u4e4b\u89c2\uff0c\u5e38\u5728\u4e8e\u9669\u8fdc\uff1a\u63a2\u7d22GPCR\u522b\u6784\u4f4d\u70b9\u7684\u865a\u62df\u7b5b\u9009\u4e4b\u9053"},"content":{"rendered":"\n
\"\"<\/a>
\u70b9\u51fb\u64ad\u653e\u89c6\u9891<\/figcaption><\/figure>\n\n\n\n

\u8bba\u6587\u4eae\u70b9<\/strong><\/p>\n\n\n\n

\u00a0\u9648\u948a\u00a0hLife Journal<\/a>2024-05-08 07:15\u5317\u4eac<\/em><\/p>\n\n\n\n

\u672c\u6587\u7cfb\u7edf\u5730\u603b\u7ed3\u4e86G\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08G-protein coupled receptors, GPCRs\uff09\u522b\u6784\u4f4d\u70b9\u7684\u7ed3\u6784\u4fe1\u606f\u548c\u8c03\u63a7\u529f\u80fd\u673a\u5236\uff0c\u5e76\u4e14\u68b3\u7406\u4e86\u76ee\u524d\u5df2\u7ecf\u53d1\u8868\u7684\u57fa\u4e8eGPCRs\u7ed3\u6784\u7684\u865a\u62df\u7b5b\u9009\uff08Structure-based virtual screening, SBVS\uff09\u7814\u7a76\uff0c\u6df1\u5165\u63a2\u8ba8\u4e86\u9776\u5411GPCRs\u522b\u6784\u4f4d\u70b9\u8fdb\u884c\u836f\u7269\u865a\u62df\u7b5b\u9009\u548c\u8bbe\u8ba1\u6240\u5177\u6709\u7684\u5e7f\u9614\u524d\u666f\u4ee5\u53ca\u9762\u4e34\u7684\u6311\u6218\u3002<\/p>\n\n\n\n

\u8bba\u6587\u5bfc\u8bfb<\/strong><\/p>\n\n\n\n

\u5317\u4eac\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\/\u6e05\u534e\u5927\u5b66\u751f\u7269\u533b\u5b66\u4ea4\u53c9\u7814\u7a76\u9662\u9ec4\u725b\u7814\u7a76\u56e2\u961f\u5728hLife<\/em>\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cExploring structure-based drug discovery of GPCRs beyond the orthosteric binding site\u201d\u7684\u7efc\u8ff0\u3002\u6587\u7ae0\u603b\u7ed3\u4e86\u76ee\u524d\u5df2\u77e5\u7ed3\u6784GPCR\u7684\u522b\u6784\u4f4d\u70b9\u53ca\u5176\u8c03\u8282\u673a\u5236\uff0c\u5728\u603b\u7ed3\u9776\u5411\u6b63\u6784\u4f4d\u70b9\u836f\u7269\u865a\u62df\u7b5b\u9009\u6210\u529f\u7ecf\u9a8c\u7684\u57fa\u7840\u4e0a\uff0c\u91cd\u70b9\u63a2\u8ba8\u4e86\u522b\u6784\u4f4d\u70b9\u8c03\u63a7\u5242\u7684\u53d1\u5c55\u6f5c\u529b\uff0c\u5e76\u4e14\u7279\u522b\u5f3a\u8c03\u4e86\u5bb9\u6613\u88ab\u5ffd\u89c6\u7684\u7ec6\u80de\u819c\u7ec4\u5206\u5728\u9488\u5bf9\u522b\u6784\u4f4d\u70b9\u8fdb\u884c\u865a\u62df\u7b5b\u9009\u8fc7\u7a0b\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u540c\u65f6\u6587\u7ae0\u4e5f\u901a\u8fc7\u5b9e\u4f8b\u8bf4\u660e\u4e86\u8d85\u5927\u89c4\u6a21\u6216\u4e13\u7528\u5316\u5408\u7269\u5e93\u5728\u53d1\u73b0\u65b0\u578b\u5c0f\u5206\u5b50\u914d\u4f53\u4ee5\u53caAI\u5728\u52a0\u901f\u865a\u62df\u7b5b\u9009\u901f\u5ea6\u4e2d\u7684\u91cd\u8981\u4ef7\u503c\u3002<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

\u626b\u7801\u9605\u8bfb\u539f\u6587<\/strong><\/p>\n\n\n\n

GPCRs\u662f\u836f\u7269\u53d1\u73b0\u4e2d\u6700\u91cd\u8981\u548c\u6700\u6210\u529f\u7684\u9776\u70b9\uff0c\u8fd1\u5e74\u6765\u9488\u5bf9GPCRs\u6b63\u6784\u4f4d\u70b9\u8fdb\u884c\u7684\u865a\u62df\u7b5b\u9009\u5df2\u7ecf\u5e7f\u6cdb\u5f00\u5c55\u3002\u968f\u7740GPCRs\u522b\u6784\u4f4d\u70b9\u7ed3\u6784\u548c\u529f\u80fd\u7814\u7a76\u7684\u6df1\u5165\u5f00\u5c55\uff0c\u9776\u5411GPCRs\u522b\u6784\u4f4d\u70b9\u8fdb\u884c\u7684\u65b0\u836f\u7814\u53d1\u4e5f\u8d8a\u6765\u8d8a\u53d7\u5230\u5173\u6ce8\u3002\u7136\u800c\uff0c\u9776\u5411GPCRs\u522b\u6784\u4f4d\u70b9\u7684\u865a\u62df\u7b5b\u9009\u9762\u4e34\u8bf8\u591a\u6311\u6218\uff0c\u9664\u4e86\u8fdb\u4e00\u6b65\u62d3\u5c55\u548c\u5b8c\u5584\u522b\u6784\u4f4d\u70b9\u7684\u7ed3\u6784\u4fe1\u606f\u4e4b\u5916\uff0c\u5982\u4f55\u5206\u6790\u548c\u63cf\u8ff0\u522b\u6784\u4f4d\u70b9\u3001\u5c0f\u5206\u5b50\u914d\u4f53\uff0c\u4ee5\u53ca\u819c\u7ec4\u5206\u4e09\u8005\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5bf9\u671d\u5411\u7ec6\u80de\u819c\u73af\u5883\u522b\u6784\u4f4d\u70b9\u7684\u865a\u62df\u7b5b\u9009\u81f3\u5173\u91cd\u8981\u3002\u540c\u65f6\uff0c\u5982\u4f55\u5feb\u901f\u51c6\u786e\u5730\u7b5b\u9009\u5230\u5168\u65b0\u7ed3\u6784\u7c7b\u578b\u7684\u914d\u4f53\u4e5f\u662f\u4e9f\u5f85\u89e3\u51b3\u7684\u91cd\u8981\u6280\u672f\u95ee\u9898\u3002<\/p>\n\n\n\n

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\"\"<\/a>
\u56fe1 A\u7c7bGPCRs\u7684\u53d8\u6784\u4f4d\u70b9\uff08\u6b63\u9762\u89c6\u89d2\uff09<\/strong>
<\/figcaption><\/figure>\n\n\n\n
\"\"<\/a>
\u56fe2 A\u7c7bGPCRs\u7684\u53d8\u6784\u4f4d\u70b9\uff08\u80cc\u9762\u89c6\u89d2\uff09<\/strong><\/figcaption><\/figure>\n\n\n\n
\"\"<\/a>
\u56fe3 B\u3001C\u3001F\u4e09\u7c7b\u7684\u53d8\u6784\u4f4d\u70b9<\/strong><\/figcaption><\/figure>\n\n\n\n

\u968f\u7740GPCRs\u522b\u6784\u4f4d\u70b9\u7ed3\u6784\u6570\u636e\u7684\u589e\u957f\uff0c\u9776\u5411GPCRs\u53d8\u6784\u4f4d\u70b9\u836f\u7269\u7684\u7b5b\u9009\u548c\u53d1\u73b0\u4e5f\u9010\u6e10\u5f97\u5230\u4e86\u5927\u5bb6\u7684\u5173\u6ce8\u3002\u6587\u7ae0\u7edf\u8ba1\u4e86\u76ee\u524d\u5df2\u7ecf\u53d1\u8868\u4e14\u6709\u53ef\u4fe1\u5b9e\u9a8c\u6570\u636e\u7684\u57fa\u4e8eGPCRs\u7ed3\u6784\u7684\u865a\u62df\u7b5b\u9009\u7814\u7a76\uff08\u603b\u8ba172\u7bc7\uff09\u3002\u7531\u4e8e\u6b63\u6784\u4f4d\u70b9\u8f83\u4e3a\u4e30\u5bcc\u7684\u7ed3\u6784\u4fe1\u606f\u548c\u6e05\u695a\u7684\u8c03\u8282\u673a\u5236\uff0c\u57fa\u4e8e\u6b63\u6784\u4f4d\u70b9\u7ed3\u6784\u8fdb\u884c\u865a\u62df\u7b5b\u9009\u76ee\u524d\u662f\u7814\u7a76\u7684\u4e3b\u6d41\uff0868\u7bc7\uff09\u3002\u9776\u5411\u53d8\u6784\u4f4d\u70b9\u7684\u865a\u62df\u7b5b\u9009\u7684\u7814\u7a76\u6570\u91cf\u5219\u76f8\u5bf9\u8f83\u5c11\uff084\u7bc7\uff09\uff0c\u5e76\u4e14\u5bf9\u4f4d\u70b9\u7684\u9009\u62e9\u90fd\u96c6\u4e2d\u5728\u6b63\u6784\u4f4d\u70b9\u4e0a\u65b9\u548c\u8de8\u819c\u87ba\u65cb\u5185\uff0c\u5176\u4ed6\u533a\u57df\u7684\u522b\u6784\u4f4d\u70b9\u7ed3\u6784\uff0c\u5c24\u5176\u662f\u5927\u91cf\u4f4d\u4e8e\u4e03\u6b21\u8de8\u819c\u87ba\u65cb\u5916\u90e8\u4e0e\u7ec6\u80de\u819c\u4ea4\u754c\u5904\u7684\u522b\u6784\u4f4d\u70b9\uff0c\u5e76\u6ca1\u6709\u88ab\u5f88\u597d\u5730\u5229\u7528\u8d77\u6765\uff0c\u5b58\u5728\u5de8\u5927\u6f5c\u529b\u3002<\/p>\n\n\n\n

\u540c\u65f6\uff0c\u6587\u7ae0\u4e5f\u8ba8\u8bba\u4e86\u8d85\u5927\u89c4\u6a21\u5206\u5b50\u5e93\u4ee5\u53ca\u4e13\u7528\u5206\u5b50\u5e93\u5728\u5168\u65b0\u7684\u836f\u7269\u5206\u5b50\u7c7b\u578b\u53d1\u73b0\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u3002\u5982LYU\u7b49\u4f7f\u75281.38\u4ebf\u5927\u5c0f\u7684\u5206\u5b50\u5e93\u5bf9D1\u53d7\u4f53\u8fdb\u884c\u4e86\u865a\u62df\u7b5b\u9009\uff0c\u7b5b\u9009\u51fa81\u4e2a\u65b0\u7684\u5206\u5b50\u7c7b\u578b\uff0c\u5176\u4e2d30\u4e2a\u5177\u6709\u4e9a\u5fae\u6469\u5c14\u7ea7\u522b\u7684\u6d3b\u6027\u3002\u53e6\u4e00\u65b9\u9762\uff0cShoichet\u7b49\u6784\u5efa\u4e86\u4e00\u4e2a\u5b9a\u5236\u7684\u542b\u6709\u56db\u6c22\u5421\u5576\u9aa8\u67b6\u7684\u5206\u5b50\u5e93\uff0c\u5728\u9776\u54115-HT2A\u7684\u865a\u62df\u7b5b\u9009\u4e2d\u4e5f\u53d6\u5f97\u4e86\u5f88\u597d\u7684\u8868\u73b0\u3002<\/p>\n\n\n\n

\u8fd1\u51e0\u5e74\u6765\uff0c\u968f\u7740AI\u6280\u672f\u7684\u5feb\u901f\u53d1\u5c55\uff0cAI\u65b9\u6cd5\u5728\u52a0\u901fGPCRs\u836f\u7269\u53d1\u73b0\u65b9\u9762\u7684\u5e94\u7528\u4e5f\u5728\u663e\u8457\u589e\u957f\u3002\u4e00\u65b9\u9762\uff0c\u751f\u6210\u5f0f\u6a21\u578b\u88ab\u5e94\u7528\u4e8e\u6784\u5efa\u5206\u5b50\u5e93\uff0c\u800cAlphaFold2\u4f7f\u5f97\u51c6\u786e\u9884\u6d4bGPCRs\u7ed3\u6784\u6210\u4e3a\u53ef\u80fd\uff0c\u4e24\u8005\u62d3\u5c55\u4e86SBVS\u7684\u5316\u5b66\u7a7a\u95f4\u548c\u9776\u70b9\u6570\u91cf\uff0c\u53e6\u4e00\u65b9\u9762\uff0cAI\u4e5f\u53ef\u4ee5\u5e2e\u52a9\u5feb\u901f\u5730\u5bf9\u8d85\u5927\u89c4\u6a21\u5206\u5b50\u5e93\u8fdb\u884c\u521d\u6b65\u7b5b\u9009\uff0c\u4ece\u800c\u52a0\u5feb\u7b5b\u9009\u901f\u5ea6\u3002<\/p>\n\n\n\n

\u6700\u540e\uff0c\u6587\u7ae0\u5c55\u671b\u4e86\u4f4d\u4e8e\u8de8\u819c\u87ba\u65cb\u548c\u7ec6\u80de\u819c\u4ea4\u754c\u5904\u7684\u522b\u6784\u4f4d\u70b9\u5728GPCRs\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u7814\u7a76\u6f5c\u529b\u548c\u9700\u8981\u89e3\u51b3\u7684\u95ee\u9898\u3002\u76ee\u524d\u5df2\u77e5\u7684GPCRs\u522b\u6784\u4f4d\u70b9\u5927\u90e8\u5206\u90fd\u90bb\u63a5\u7ec6\u80de\u819c\uff08\u56fe4\uff09\uff0c\u9488\u5bf9\u8fd9\u4e9b\u4f4d\u70b9\u8fdb\u884c\u836f\u7269\u7b5b\u9009\u548c\u5f00\u53d1\u6709\u7740\u5de8\u5927\u7684\u7814\u7a76\u6f5c\u529b\u548c\u4ef7\u503c\u3002\u7136\u800c\u5728\u5927\u90e8\u5206GPCRs\u7ed3\u6784\u4e2d\u8fd9\u4e9b\u7ec6\u80de\u819c\u7ec4\u5206\u7684\u4fe1\u606f\u662f\u7f3a\u5931\u7684\uff0c\u56e0\u6b64\u5982\u4f55\u901a\u8fc7\u5408\u7406\u7684\u8ba1\u7b97\u624b\u6bb5\u53bb\u6a21\u62df\u8bc4\u4f30\u8102\u8d28\u5206\u5b50\u5bf9\u5c0f\u5206\u5b50\u7ed3\u5408\u7684\u5f71\u54cd\u662f\u9776\u5411\u8fd9\u4e9b\u522b\u6784\u4f4d\u70b9\u8fdb\u884c\u865a\u62df\u7b5b\u9009\u7684\u4e9f\u9700\u89e3\u51b3\u7684\u96be\u9898\u3002<\/p>\n\n\n\n

\"\"<\/a>
\u56fe4 \u4e0e\u8102\u8d28\u548c\u56fa\u9187\u6709\u76f8\u4e92\u4f5c\u7528\u7684GPCRs\u522b\u6784\u8c03\u8282\u5242<\/figcaption><\/figure>\n\n\n\n

\u603b\u4f53\u800c\u8a00\uff0c\u4ece\u65b0\u836f\u7814\u53d1\u5386\u53f2\u6765\u770b\uff0c\u7ea6\u670935%\u7684FDA\u6279\u51c6\u4e0a\u5e02\u836f\u7269\u662f\u9776\u5411GPCRs\uff0c\u4f46\u5176\u4e2d\uff08\u7edd\uff09\u5927\u90e8\u5206\u90fd\u662f\u901a\u8fc7\u4f20\u7edf\u7684\u836f\u7269\u7b5b\u9009\u548c\u7814\u53d1\u6a21\u5f0f\u627e\u5230\u3002\u5982\u4f55\u5728\u4f4e\u60ac\u679c\u5b9e\u5df2\u88ab\u4f20\u7edf\u836f\u7269\u7b5b\u9009\u6458\u53d6\u540e\u505a\u51fa\u65b0\u610f\uff1f\u8fd1\u5e74\u6765GPCRs\u86cb\u767d\u7ed3\u6784\u89e3\u6790\u65e5\u65b0\u6708\u5f02\uff0c\u6781\u5927\u62d3\u5c55\u4e86\u5bf9GPCR\u6fc0\u6d3b\u548c\u62ee\u6297\u673a\u7406\u673a\u5236\u7684\u8ba4\u77e5\uff0c\u8b6c\u5982\u504f\u5411\u6027\u4fe1\u53f7\u4f20\u5bfc\u4e0eGPCR\u86cb\u767d\u4e0d\u540c\u6784\u8c61\u72b6\u6001\u7d27\u5bc6\u76f8\u5173\u3002\u53e4\u4eba\u5e38\u8bf4\uff0c\u201c\u975e\u5e38\u4e4b\u89c2\uff0c\u5e38\u5728\u4e8e\u9669\u8fdc\u3002\u6709\u5fd7\u77e3\uff0c\u4e0d\u968f\u4ee5\u6b62\u4e5f\uff0c\u7136\u529b\u4e0d\u8db3\u8005\uff0c\u4ea6\u4e0d\u80fd\u81f3\u4e5f\u3002\u201d\u8fd9\u91cc\u7684\u529b\uff0c\u5728GPCRs\u6216\u8bb8\u5c31\u662f\u522b\u6784\u4e4b\u529b\u3002\u6df1\u5165\u89e3\u8bfbGPCR\u86cb\u767d\u4e09\u7ef4\u7ed3\u6784\u63d0\u4f9b\u7684\u65b0\u7ef4\u5ea6\u4fe1\u606f\uff0c\u5c24\u5176\u662f\u522b\u6784\u4f4d\u70b9\u4fe1\u606f\uff0c\u5229\u7528\u5c0f\u5206\u5b50\u5316\u5408\u7269\u548c\u522b\u6784\u4f4d\u70b9\u7684\u4f5c\u7528\u529b\uff0c\u8bf1\u5bfcGPCR\u86cb\u767d\u65b0\u6784\u8c61\uff0c\u63a2\u7d22GPCR\u86cb\u767d\u65b0\u673a\u5236\uff0c\u8e0f\u4e0a\u5947\u4f1f\u3001\u7470\u602a\u7684\u60ca\u559c\u4e4b\u65c5\u3002<\/p>\n\n\n\n

\u2726 <\/p>\n\n\n\n

\u4f5c\u8005\u7b80\u4ecb<\/p>\n\n\n\n

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\u9648\u948a \u535a\u58eb\u751f<\/strong>  \u7b2c\u4e00\u4f5c\u8005<\/figcaption><\/figure>\n\n\n\n

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\u5f15\u7528\u683c\u5f0f\uff1aChen Z, Ren X, Zhou Y, et. al. Exploring structure-based drug discovery of GPCRs beyond the orthosteric binding site. hLife<\/em>.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u8bba\u6587\u4eae\u70b9 \u00a0\u9648\u948a\u00a0hLife Journal2024-05-08 07:15\u5317\u4eac \u672c\u6587\u7cfb\u7edf\u5730\u603b\u7ed3\u4e86G\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08G-protein coupled receptors, GPCRs\uff09\u522b\u6784\u4f4d\u70b9\u7684\u7ed3\u6784\u4fe1\u606f\u548c\u8c03\u63a7\u529f\u80fd\u673a\u5236\uff0c\u5e76\u4e14\u68b3\u7406\u4e86\u76ee\u524d\u5df2\u7ecf\u53d1\u8868\u7684\u57fa\u4e8eGPCRs\u7ed3\u6784\u7684\u865a\u62df\u7b5b\u9009\uff08Structure-based virtual screening, SBVS\uff09\u7814\u7a76\uff0c\u6df1\u5165\u63a2\u8ba8\u4e86\u9776\u5411GPCRs\u522b\u6784\u4f4d\u70b9\u8fdb\u884c\u836f\u7269\u865a\u62df\u7b5b\u9009\u548c\u8bbe\u8ba1\u6240\u5177\u6709\u7684\u5e7f\u9614\u524d\u666f\u4ee5\u53ca\u9762\u4e34\u7684\u6311\u6218\u3002 \u8bba\u6587\u5bfc\u8bfb \u5317\u4eac\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\/\u6e05\u534e\u5927\u5b66\u751f\u7269\u533b\u5b66\u4ea4\u53c9\u7814\u7a76\u9662\u9ec4\u725b\u7814\u7a76\u56e2\u961f\u5728hLife\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cExploring structure-based drug discovery of GPCRs beyond the orthosteric binding site\u201d\u7684\u7efc\u8ff0\u3002\u6587\u7ae0\u603b\u7ed3\u4e86\u76ee\u524d\u5df2\u77e5\u7ed3\u6784GPCR\u7684\u522b\u6784\u4f4d\u70b9\u53ca\u5176\u8c03\u8282\u673a\u5236\uff0c\u5728\u603b\u7ed3\u9776\u5411\u6b63\u6784\u4f4d\u70b9\u836f\u7269\u865a\u62df\u7b5b\u9009\u6210\u529f\u7ecf\u9a8c\u7684\u57fa\u7840\u4e0a\uff0c\u91cd\u70b9\u63a2\u8ba8\u4e86\u522b\u6784\u4f4d\u70b9\u8c03\u63a7\u5242\u7684\u53d1\u5c55\u6f5c\u529b\uff0c\u5e76\u4e14\u7279\u522b\u5f3a\u8c03\u4e86\u5bb9\u6613\u88ab\u5ffd\u89c6\u7684\u7ec6\u80de\u819c\u7ec4\u5206\u5728\u9488\u5bf9\u522b\u6784\u4f4d\u70b9\u8fdb\u884c\u865a\u62df\u7b5b\u9009\u8fc7\u7a0b\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u540c\u65f6\u6587\u7ae0\u4e5f\u901a\u8fc7\u5b9e\u4f8b\u8bf4\u660e\u4e86\u8d85\u5927\u89c4\u6a21\u6216\u4e13\u7528\u5316\u5408\u7269\u5e93\u5728\u53d1\u73b0\u65b0\u578b\u5c0f\u5206\u5b50\u914d\u4f53\u4ee5\u53caAI\u5728\u52a0\u901f\u865a\u62df\u7b5b\u9009\u901f\u5ea6\u4e2d\u7684\u91cd\u8981\u4ef7\u503c\u3002 \u626b\u7801\u9605\u8bfb\u539f\u6587 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