{"id":1202,"date":"2023-02-09T11:30:40","date_gmt":"2023-02-09T03:30:40","guid":{"rendered":"https:\/\/www.huanglab.org.cn\/wordpress\/?p=1202"},"modified":"2023-02-09T19:24:47","modified_gmt":"2023-02-09T11:24:47","slug":"acs-central-science-%e4%bb%a5%e4%b8%8d%e5%8f%98%e5%ba%94%e4%b8%87%e5%8f%98%ef%bc%9a%e9%bb%84%e7%89%9b%e5%ae%9e%e9%aa%8c%e5%ae%a4%e5%88%a9%e7%94%a8%e8%99%9a%e6%8b%9f%e7%ad%9b%e9%80%89%e6%96%b9","status":"publish","type":"post","link":"https:\/\/www.huanglab.org.cn\/wordpress\/?p=1202","title":{"rendered":"ACS Central Science | \u4ee5\u4e0d\u53d8\u5e94\u4e07\u53d8\uff1a\u9ec4\u725b\u5b9e\u9a8c\u5ba4\u5229\u7528\u865a\u62df\u7b5b\u9009\u65b9\u6cd5\u53d1\u73b0\u53ef\u8c03\u63a7\u65b0\u51a0\u75c5\u6bd2\u523a\u7a81\u86cb\u767d\u6784\u8c61\u8f6c\u53d8\u7684\u5c0f\u5206\u5b50\u8c03\u8282\u5242"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large is-resized\"><a href=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/wangq.jpg\"><img loading=\"lazy\" src=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/wangq-768x1024.jpg\" alt=\"\" class=\"wp-image-1214\" width=\"176\" height=\"235\" srcset=\"https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/wangq-768x1024.jpg 768w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/wangq-225x300.jpg 225w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/wangq.jpg 864w\" sizes=\"(max-width: 176px) 100vw, 176px\" \/><\/a><figcaption>\u738b\u60c5 \u535a\u58eb\u751f\uff0c\u672c\u6587\u7684\u7b2c\u4e00\u4f5c\u8005<\/figcaption><\/figure>\n\n\n\n<p>ACS Central Science | 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controls=\"\" autoplay=\"\">\n   <source src=\"\/wq.mp4\">\n<\/video>\n\n\n\n<p><strong>\u89c6\u9891<\/strong><strong>1<\/strong> \u878d\u5408\u524dspike\u86cb\u767d\u7684\u4e24\u79cd\u6784\u8c61\u72b6\u6001 <\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u8fd9\u4e09\u5e74\u6765\uff0c\u8086\u8650\u5168\u7403\u7684\u65b0\u51a0\u75c5\u6bd2\u53d8\u5316\u591a\u7aef\uff0c\u4ece\u539f\u59cb\u682a\u5f00\u59cb\uff0c\u6f14\u5316\u51fa\u963f\u5c14\u6cd5\u3001\u8d1d\u5854\u3001\u4f3d\u9a6c\u3001\u5fb7\u5c14\u5854\uff0c\u76f4\u5230\u73b0\u5728\u5965\u5bc6\u514b\u620e\u53c8\u6210\u4e3a\u6700\u6d41\u884c\u6bd2\u682a\uff0c\u8fd8\u5206\u5316\u51fa\u4e0d\u540c\u4e9a\u578b\uff0c\u81f3\u4e8e\u5c06\u6765\u5982\u4f55\u53d8\u5e7b\uff0c\u96be\u4ee5\u9884\u6599\u3002\u4f46\u4e07\u53d8\u4e0d\u79bb\u5176\u5b97\uff0c\u65b0\u51a0\u75c5\u6bd2\u518d\u53d8\u5e7b\u65e0\u7a77\uff0c\u4e5f\u4ecd\u7136\u9075\u5faa\u75c5\u6bd2\u7684\u751f\u6d3b\u53f2\uff0c\u9075\u5faa\u5438\u9644\u3001\u8fdb\u5165\u3001\u8131\u58f3\u3001\u590d\u5236\u3001\u6210\u719f\u548c\u91ca\u653e\u7684\u751f\u547d\u5468\u671f\u3002\u9488\u5bf9\u65b0\u51a0\u75c5\u6bd2\u8fdb\u884c\u7684\u65b0\u836f\u7814\u53d1\u4e5f\u662f\u56f4\u7ed5\u7740\u8fd9\u51e0\u4e2a\u5173\u952e\u8282\u70b9\u8fdb\u884c\u3002\u6291\u5236\u5df2\u5165\u4fb5\u7ec6\u80de\u7684\u75c5\u6bd2\u590d\u5236\u5df2\u6709\u591a\u4e2a\u5c0f\u5206\u5b50\u836f\u7269\u6279\u51c6\u4e0a\u5e02\u6216\u8005\u7d27\u6025\u4f7f\u7528\u6388\u6743\uff0c\u59823CL\u86cb\u767d\u9176\u6291\u5236\u5242Paxlovid\u548cEnsitrelvir\uff0c\u5982RdRp\u6291\u5236\u5242Remdesivir\u548cMolnupiravir\u3002\u4f46\u76f4\u63a5\u963b\u65ad\u65b0\u51a0\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\u7684\u9014\u5f84\uff0c\u5c1a\u672a\u6709\u4e00\u6b3e\u5c0f\u5206\u5b50\u836f\u7269\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\uff0c\u867d\u7136\u8fd9\u6761\u9014\u5f84\u5df2\u7ecf\u88ab\u6297\u4f53\u548c\u75ab\u82d7\u9a8c\u8bc1\u4e86\u5176\u53ef\u884c\u6027\uff0c\u4f46\u8fd9\u7c7b\u751f\u7269\u836f\u5374\u7ecf\u5e38\u56e0\u4e3a\u65b0\u51a0\u75c5\u6bd2spike\u86cb\u767d\u53d8\u5f02\u800c\u5931\u6548\u30022020\u5e74Toelzer\u7b49\u4eba\u5728Science\u7b49\u6742\u5fd7\u8fde\u7eed\u53d1\u6587\uff0c\u53d1\u73b0spike\u86cb\u767d\u867d\u7136\u591a\u53d8\uff0c\u5374\u5177\u6709\u4e00\u4e2a\u975e\u5e38\u4fdd\u5b88\u7684\u6e38\u79bb\u8102\u80aa\u9178\uff08free fatty acid, FFA\uff09\u7ed3\u5408\u4f4d\u70b9\uff0c\u8c03\u63a7\u8be5\u4f4d\u70b9\u53ef\u4ee5\u6709\u6548\u5730\u6291\u5236\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\uff0c\u79f0\u5176\u4e3a\u65b0\u51a0\u7684\u963f\u5580\u7409\u65af\u4e4b\u8e35\u3002\u53ef\u60dc\u7684\u662f\uff0c\u56e0\u4e3a\u5176\u7ed3\u5408\u4f4d\u70b9\u7684\u7279\u6b8a\u6027\uff0c\u53ea\u62a5\u9053\u8fc7\u51e0\u4e2a\u5076\u7136\u53d1\u73b0\u7684\u5929\u7136\u4ea7\u7269\uff0c\u5c1a\u672a\u627e\u5230\u53ef\u6210\u836f\u7684\u5c0f\u5206\u5b50\u3002<\/p>\n\n\n\n<p>\u90a3\u4e48\uff0c\u9762\u5bf9\u65b0\u51a0\u591a\u53d8\u7684spike\u86cb\u767d\uff0c\u4ee5\u4e0d\u53d8\u5e94\u4e07\u53d8\uff0c\u662f\u5426\u53ef\u4ee5\u901a\u8fc7\u57fa\u4e8e\u7ed3\u6784\u7684\u865a\u62df\u7b5b\u9009\uff0c\u7cbe\u786e\u5730\u9776\u5411\u65b0\u51a0\u75c5\u6bd2\u7684\u4e03\u5bf8\u2014\u2014\u6e38\u79bb\u8102\u80aa\u9178\u7ed3\u5408\u4f4d\u70b9\u2014\u2014\u5c04\u51fa\u8fd9\u4e00\u7bad\uff1f<\/p>\n\n\n\n<p>2023\u5e742\u67088\u65e5\uff0c\u5317\u4eac\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\/\u6e05\u534e\u5927\u5b66\u751f\u7269\u533b\u5b66\u4ea4\u53c9\u7814\u7a76\u9662\u9ec4\u725b\u5b9e\u9a8c\u5ba4\u4e0e\u5929\u6d25\u5927\u5b66\u836f\u5b66\u9662\u9ec4\u5251\u8f89\u6559\u6388\u53ca\u6c34\u6728\u672a\u6765\uff08\u5317\u4eac\uff09\u79d1\u6280\u6709\u9650\u516c\u53f8\u5408\u4f5c\uff0c\u5728\u7f8e\u56fd\u5316\u5b66\u4f1a\u65d7\u8230\u6742\u5fd7ACS Central Science\u6742\u5fd7\u4e0a\u53d1\u8868\u9898\u4e3a\u201cIn Silico Discovery of Small Molecule Modulators Targeting the Achilles&#8217; Heel of SARS-CoV-2 Spike Protein\u201d\u7684\u6587\u7ae0\u3002\u8be5\u7814\u7a76\u9488\u5bf9SARS-CoV-2 spike\u86cb\u767d\u4fdd\u5b88\u7684\u6e38\u79bb\u8102\u80aa\u9178\uff08free fatty acid, FFA\uff09\u7ed3\u5408\u4f4d\u70b9\uff0c\u901a\u8fc7\u5927\u89c4\u6a21\u865a\u62df\u7b5b\u9009\u7b56\u7565\u53d1\u73b0\u82d7\u5934\u5316\u5408\u7269\u5e76\u968f\u540e\u5bf9\u5176\u8fdb\u884c\u4f18\u5316\uff0c\u5f97\u5230\u4e00\u7cfb\u5217\u4f4e\u6469\u5c14\u7ea7\u522b\u7ed3\u5408\u6d3b\u6027\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u3002\u968f\u540e\u51b7\u51bb\u7535\u955c\u7814\u7a76\u786e\u5b9a\u4e86\u5c0f\u5206\u5b50\u5728FFA\u7ed3\u5408\u4f4d\u70b9\u7684\u7ed3\u5408\u6a21\u5f0f\uff0c\u5e76\u4e14\u63ed\u793a\u4e86\u5c0f\u5206\u5b50\u7684\u7ed3\u5408\u4f7fspike\u86cb\u767d\u7684\u6784\u8c61\u5e73\u8861\u5411\u201c\u95ed\u5408\u201d\u72b6\u6001\u65b9\u5411\u8f6c\u53d8\uff0c\u5373\u65e0\u6cd5\u4e0eACE2\u53d7\u4f53\u7ed3\u5408\u7684\u6784\u8c61\u72b6\u6001\u3002\u8be5\u7814\u7a76\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u8868\u660e\u9488\u5bf9\u4fdd\u5b88\u7684FFA\u7ed3\u5408\u4f4d\u70b9\u53d1\u73b0\u7684\u5c0f\u5206\u5b50\u8c03\u8282\u5242\u6709\u671b\u5f00\u53d1\u6210\u4e3a\u9884\u9632\u548c\u6cbb\u7597\u51a0\u72b6\u75c5\u6bd2\u7684\u5e7f\u8c31\u836f\u7269\uff0c\u5e76\u4e14\u8054\u5408\u5176\u4ed6\u4f5c\u7528\u673a\u5236\u7684\u836f\u7269\u59823CL\u86cb\u767d\u9176\u6291\u5236\u5242\u7b49\uff0c\u8fbe\u5230\u9e21\u5c3e\u9152\u7597\u6cd5\u7684\u6548\u679c\u3002<\/p>\n\n\n\n<ol type=\"1\"><li>\u201c\u65b0\u836f\u53d1\u73b0\u7684\u6e90\u6cc9\u201d\u2014\u2014\u751f\u7269\u5b66\u65b0\u673a\u5236<\/li><\/ol>\n\n\n\n<p>\u65b0\u836f\u7814\u53d1\u7684\u6e90\u6cc9\u662f\u65b0\u7684\u751f\u7269\u5b66\u673a\u5236\/\u65b0\u9776\u70b9\u3002SARS-CoV-2\u5229\u7528\u5176\u5305\u819c\u4e0a\u7684\u4e09\u805a\u4f53spike\u86cb\u767d\u4e0e\u5bbf\u4e3b\u7ec6\u80deACE2\u53d7\u4f53\u7ed3\u5408\u4ee5\u4ecb\u5bfc\u75c5\u6bd2\u7684\u5165\u4fb5\u3002\u878d\u5408\u524d\u7684spike\u86cb\u767d\u4e3b\u8981\u6709\u4e24\u79cd\u6784\u8c61\u72b6\u6001\uff0c\u4e00\u79cd\u662f\u4e09\u4e2a\u53d7\u4f53\u7ed3\u5408\u57df\uff08receptor-binding domain\uff0cRBD\uff09\u90fd\u5904\u4e8e\u201c\u5411\u4e0b\u201d\u6784\u8c61\u7684\u201c\u95ed\u5408\u201d\u72b6\u6001\uff08\u56fe1A\uff09\uff0c\u53e6\u4e00\u79cd\u662f\u6709\u4e00\u4e2a\u6216\u591a\u4e2aRBD\u5904\u4e8e\u201c\u5411\u4e0a\u201d\u6784\u8c61\u7684\u201c\u5f00\u653e\u201d\u72b6\u6001\uff0c\u800c\u53ea\u6709\u201c\u5411\u4e0a\u201d\u6784\u8c61\u7684RBD\u624d\u80fd\u4e0eACE2\u7ed3\u5408\uff08\u56fe1B\uff09\u3002\u4e0e\u65b0\u51a0\u75c5\u6bd2\u539f\u59cb\u682a\u76f8\u6bd4\uff0c\u8ba1\u7b97\u6a21\u62df\u53ca\u7ed3\u6784\u751f\u7269\u5b66\u7814\u7a76\u5747\u8868\u660e\u8fd1\u671f\u6d41\u884c\u7684\u5965\u5bc6\u514b\u620e\u53d8\u5f02\u682a\u7684spike\u86cb\u767d\u6784\u8c61\u66f4\u504f\u597d\u4e0eACE2\u7ed3\u5408\u7684\u201c\u5f00\u653e\u201d\u72b6\u6001\uff0c\u8fd9\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u89e3\u91ca\u4e86\u5965\u5bc6\u514b\u620e\u6bd2\u682a\u4f20\u64ad\u6027\u66f4\u5f3a\u7684\u73b0\u8c61\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22001-1.png\"><img loading=\"lazy\" width=\"1024\" height=\"852\" src=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22001-1-1024x852.png\" alt=\"\" class=\"wp-image-1204\" srcset=\"https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22001-1-1024x852.png 1024w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22001-1-300x250.png 300w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22001-1-768x639.png 768w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22001-1.png 1111w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<p><strong>\u56fe<\/strong><strong>1<\/strong> \u878d\u5408\u524dspike\u86cb\u767d\u7684\u4e24\u79cd\u6784\u8c61\u72b6\u6001\uff1a\u201c\u95ed\u5408\u201d\uff08\u5de6\uff09\u548c\u201c\u5f00\u653e\u201d\uff08\u53f3\uff09<\/p>\n\n\n\n<p>Toelzer\u7b49\u4eba\u5728\u7535\u955c\u7814\u7a76\u4e2d\u610f\u5916\u53d1\u73b0\u4e9a\u6cb9\u9178\u5206\u5b50\u7ed3\u5408\u5728\u4e09\u4e2a\u7531spike\u86cb\u767d\u4e2d\u7684\u4e24\u4e2a\u76f8\u90bbRBDs\u7ec4\u6210\u7684\u590d\u5408\u578b\u7ed3\u5408\u53e3\u888b\u4e2d\u3002\u4e0eapo spike\u76f8\u6bd4\uff0c\u4e9a\u6cb9\u9178\u7684\u7ed3\u5408\u4f7f\u5f97spike\u86cb\u767d\u4e2d\u4e09\u4e2aRBDs\u4e4b\u95f4\u7684\u7ed3\u5408\u66f4\u52a0\u7d27\u5bc6\uff0c\u5c06spike\u6784\u8c61\u9501\u5b9a\u5728\u65e0\u6cd5\u4e0eACE2\u7ed3\u5408\u7684\u201c\u95ed\u5408\u201d\u72b6\u6001\u3002\u968f\u540e\uff0c\u5317\u4eac\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u7684\u90d1\u4e09\u591a\u5b9e\u9a8c\u5ba4\u4e5f\u6709\u7c7b\u4f3c\u53d1\u73b0\u3002\u672c\u7814\u7a76\u56e2\u961f\u5bf9\u6b64FFA\u7ed3\u5408\u4f4d\u70b9\u6c28\u57fa\u9178\u6b8b\u57fa\u7684\u4fdd\u5b88\u6027\u8fdb\u884c\u4e86\u5206\u6790\uff0c\u53d1\u73b0\u9664R408\u5916\uff0c\u5176\u4ed6\u6b8b\u57fa\u90fd\u9ad8\u5ea6\u4fdd\u5b88\uff0c\u4fdd\u5b88\u6027\u8fdc\u8fdc\u9ad8\u4e8e\u4e0eACE2\u7ed3\u5408\u754c\u9762\u5904\u7684\u6b8b\u57fa\uff08\u56fe2\uff09\u3002<strong>\u8fd9\u542f\u53d1\u7814\u7a76\u56e2\u961f\uff0c\u9488\u5bf9\u6b64\u4fdd\u5b88\u7684<\/strong><strong>FFA<\/strong><strong>\u7ed3\u5408\u4f4d\u70b9\u5f00\u53d1\u5c0f\u5206\u5b50\u8c03\u8282\u5242\uff0c\u6709\u671b\u4ee5\u53d8\u6784\u8c03\u8282\u7684\u65b9\u5f0f\u6539\u53d8<\/strong><strong>spike<\/strong><strong>\u86cb\u767d\u7684\u6784\u8c61\u504f\u597d\uff0c\u8fdb\u800c\u5e72\u6270\u75c5\u6bd2\u4fb5\u67d3\u7ec6\u80de\u7684\u8fc7\u7a0b\u3002<\/strong><strong><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22002-1.png\"><img loading=\"lazy\" width=\"975\" height=\"393\" src=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22002-1.png\" alt=\"\" class=\"wp-image-1205\" srcset=\"https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22002-1.png 975w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22002-1-300x121.png 300w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22002-1-768x310.png 768w\" sizes=\"(max-width: 975px) 100vw, 975px\" \/><\/a><\/figure>\n\n\n\n<p><strong>\u56fe<\/strong><strong>2<\/strong> \uff08A\uff09FFA\u7ed3\u5408\u4f4d\u70b9\u6b8b\u57fa\u4e0e\uff08B\uff09ACE2\u7ed3\u5408\u754c\u9762\u5904\u6b8b\u57fa\u7684\u4fdd\u5b88\u6027\u6bd4\u8f83<\/p>\n\n\n\n<ul><li>\u201c\u96ea\u4e2d\u9001\u70ad\u201d\u2014\u2014\u57fa\u4e8e\u9776\u6807\u7ed3\u6784\u7684\u865a\u62df\u7b5b\u9009<\/li><\/ul>\n\n\n\n<p>\u89e3\u51b3\u4f20\u7edf\u65b9\u6cd5\u5f88\u96be\u89e3\u51b3\u7684\u95ee\u9898\uff0c\u662f\u65b0\u6280\u672f\u7684\u91cd\u8981\u4ef7\u503c\u6240\u5728\u3002\u5f00\u53d1spike\u86cb\u767d\u7684\u5c0f\u5206\u5b50\u6784\u8c61\u8c03\u8282\u5242\uff0c\u96be\u4ee5\u901a\u8fc7\u5efa\u7acb\u9ad8\u901a\u91cf\u5b9e\u9a8c\u7b5b\u9009\u65b9\u6cd5\u8fdb\u884c\uff0c\u56e0\u6b64\u57fa\u4e8e\u7ed3\u6784\u7684\u865a\u62df\u7b5b\u9009\u65b9\u6cd5\u6210\u4e3a\u5bfb\u627eFFA\u7ed3\u5408\u4f4d\u70b9\u5c0f\u5206\u5b50\u914d\u4f53\u7684\u4e00\u628a\u5229\u5668\u3002\u7814\u7a76\u56e2\u961f\u9488\u5bf9FFA\u7ed3\u5408\u53e3\u888b\uff0c\u5229\u7528\u9ec4\u725b\u5b9e\u9a8c\u5ba4\u591a\u5e74\u53d1\u5c55\u7684\u9010\u7ea7\u865a\u62df\u7b5b\u9009\u6280\u672f\uff08\u56fe3\uff09\uff0c\u5148\u5bf9\u5317\u751f\u6240\u5185\u90e8\u7684\u5316\u5408\u7269\u5e93\uff0832\u4f59\u4e07\u5206\u5b50\uff09\u8fdb\u884c\u5206\u5b50\u5bf9\u63a5\uff0c\u63a5\u7740\u5bf9\u6253\u5206\u6392\u540d\u524d6\u4e07\u7684\u5316\u5408\u7269\u505a\u66f4\u9ad8\u8ba1\u7b97\u7cbe\u5ea6\u7684\u57fa\u4e8eMM-GB\/SA\u65b9\u6cd5\u7684\u4f18\u5316\u53ca\u91cd\u6253\u5206\uff0c\u968f\u540e\u7cfb\u7edf\u5206\u6790\u6253\u5206\u6392\u540d\u524d1000\u7684\u5316\u5408\u7269\u7ed3\u5408\u6a21\u5f0f\uff0c\u6700\u7ec8\u6311\u53d6\u4e8654\u4e2a\u5316\u5408\u7269\u505aSPR\u5b9e\u9a8c\u9a8c\u8bc1\uff08\u56fe3A\uff09\u3002\u7ed3\u679c\u8868\u660e\uff0c6\u4e2a\u5316\u5408\u7269\u663e\u793a\u5fae\u6469\u5c14\u7ea7\u522b\u7684\u7ed3\u5408\u6d3b\u6027\uff08\u56fe3B\uff09\u3002\u4e3a\u4e86\u63d0\u9ad8\u5316\u5408\u7269\u7684\u6d3b\u6027\u53ca\u6eb6\u89e3\u6027\uff0c\u5728\u7ecf\u8fc7\u53ef\u5408\u6210\u6027\u8bc4\u4f30\u540e\uff0c\u7814\u7a76\u56e2\u961f\u5408\u6210\u4e86SPC-2\u7684\u542b\u7fa7\u57fa\u57fa\u56e2\u7684\u7c7b\u4f3c\u7269\uff0c\u5f97\u5230\u7ed3\u5408\u6d3b\u6027\u4e3a4.8\u5fae\u6469\u5c14\u7684\u5316\u5408\u7269\uff08\u56fe4\uff09\u3002\u5e76\u4e14\uff0c\u8fd9\u7c7b\u5316\u5408\u7269\u5bf9\u5965\u5bc6\u514b\u620eBA.4\uff08spike\u86cb\u767d\u5305\u542bR408S\u7a81\u53d8\uff09\u4e5f\u8868\u73b0\u51fa\u7c7b\u4f3c\u7ed3\u5408\u6d3b\u6027\uff0c\u8868\u660e\u5316\u5408\u7269\u7684\u7ed3\u5408\u4e0d\u53d7R408\u7a81\u53d8\u7684\u5f71\u54cd\u3002\u8fd9\u4e2a\u7ed3\u679c\uff0c\u9664\u518d\u6b21\u9a8c\u8bc1\u4e86\u6211\u4eec\u8ba1\u7b97\u6280\u672f\u7684\u5b9e\u6218\u80fd\u529b\u4e4b\u5916\uff0c\u4e5f\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u4f50\u8bc1\u4e86\u6211\u4eec\u201c\u4ee5\u4e0d\u53d8\u5e94\u4e07\u53d8\u201d\u7684\u7b56\u7565\uff0c\u7528\u5c0f\u5206\u5b50\u8c03\u63a7\u4fdd\u5b88\u7684FFA\u7ed3\u5408\u53e3\u888b\uff0c\u9488\u5bf9\u6613\u7a81\u53d8\u7684\u65b0\u51a0\u75c5\u6bd2\u5177\u6709\u4e00\u5b9a\u7684\u4f18\u52bf\u3002<\/p>\n\n\n\n<h1><a rel=\"noreferrer noopener\" href=\"https:\/\/mp.weixin.qq.com\/s\/DmNxdfAfUnew3l-Y6GL4Yw\" target=\"_blank\">\u6070\u5982\u9ec4\u725b\u5b9e\u9a8c\u5ba4\u6700\u8fd1\u5728<em>Int J Mol Sci<\/em>\u5e94\u9080\u53d1\u8868\u7684\u7efc\u8ff0\u6027\u8bba\u6587\u4e2d\u5f3a\u8c03\u7684\uff0c\u865a\u62df\u7b5b\u9009\u6280\u672f\u53ea\u6709\u88ab\u7528\u5728\u65b0\u9776\u6807\u4e0a\uff0c\u53d1\u73b0\u751f\u7269\u6d3b\u6027\u5206\u5b50\u4f5c\u4e3a\u5148\u5bfc\u5316\u5408\u7269\u8fdb\u884c\u540e\u7ee7\u5f00\u53d1\uff0c\u6216\u4f5c\u4e3a\u5316\u5b66\u63a2\u9488\u6765\u7814\u7a76\u7ec6\u80de\u548c\u751f\u7269\u4f53\u4e2d\u7684\u9776\u6807\u529f\u80fd\uff0c\u624d\u80fd\u4e3a\u65b0\u836f\u7814\u53d1\u505a\u51fa\u201c\u96ea\u4e2d\u9001\u70ad\u201d\u7684\u5b9e\u8d28\u6027\u8d21\u732e<\/a>\u3002<\/h1>\n\n\n\n<h1>&nbsp;<\/h1>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22003-1.png\"><img loading=\"lazy\" width=\"1024\" height=\"721\" src=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22003-1-1024x721.png\" alt=\"\" class=\"wp-image-1206\" srcset=\"https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22003-1-1024x721.png 1024w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22003-1-300x211.png 300w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22003-1-768x541.png 768w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22003-1.png 1269w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<p><strong>\u56fe<\/strong><strong>3<\/strong> \uff08A\uff09\u9010\u7ea7\u865a\u62df\u7b5b\u9009\u7b56\u7565\u6d41\u7a0b\u56fe\u53ca\u5176\uff08B\uff09\u53d1\u73b0\u7684\u82d7\u5934\u5316\u5408\u7269<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22004-1.png\"><img loading=\"lazy\" width=\"1024\" height=\"216\" src=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22004-1-1024x216.png\" alt=\"\" class=\"wp-image-1207\" srcset=\"https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22004-1-1024x216.png 1024w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22004-1-300x63.png 300w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22004-1-768x162.png 768w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22004-1.png 1274w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<p><strong>\u56fe<\/strong><strong>4<\/strong> \u82d7\u5934\u5316\u5408\u7269\u7684SAR\u7814\u7a76<\/p>\n\n\n\n<ul><li>\u201c\u6709\u56fe\u6709\u771f\u76f8\u201d \u2014\u2014\u590d\u5408\u7269\u7ed3\u6784\u7684\u6d4b\u5b9a<\/li><\/ul>\n\n\n\n<p>\u4e3a\u4e86\u786e\u5b9a\u5316\u5408\u7269\u7684\u7ed3\u5408\u6a21\u5f0f\u53ca\u5176\u5bf9spike\u86cb\u767d\u6784\u8c61\u504f\u597d\u7684\u5f71\u54cd\uff0c\u7814\u7a76\u56e2\u961f\u5c06\u7eaf\u5316\u7684spike\u86cb\u767d\u4e0e\u542b\u7fa7\u57fa\u5316\u5408\u7269SPC-14\uff08<em>K<\/em><sub>D<\/sub> = 9.5 \u03bcM\uff09\u4e00\u8d77\u5b75\u80b2\u5236\u5907\u51b7\u51bb\u7535\u955c\u6837\u54c1\uff0c\u5e76\u4ee5\u5355\u72ec\u7684spike\u86cb\u767d\u4f53\u7cfb\u4f5c\u4e3a\u7a7a\u767d\u5bf9\u7167\u3002\u7535\u955c\u7ed3\u679c\u8868\u660e\uff0c\u5bf9\u4e8e\u6709SPC-14\u52a0\u5165\u7684\u4f53\u7cfb\uff0c\u7ea648%\u7684\u7c92\u5b50\u5904\u4e8e\u201c\u5173\u95ed\u201d\u72b6\u6001\uff0c\u53e6\u591652%\u5904\u4e8e\u6709\u4e00\u4e2aRBD\u5411\u4e0a\u7684\u201c\u5f00\u653e\u201d\u72b6\u6001\u3002\u800c\u5bf9\u4e8eapo spike\u4f53\u7cfb\uff0c\u51e0\u4e4e100% \u90fd\u5904\u4e8e\u4e00\u4e2aRBD\u5411\u4e0a\u7684\u201c\u5f00\u653e\u201d\u72b6\u6001\uff0c\u8fd9\u8868\u660eSPC-14\u7684\u52a0\u5165\u4f1a\u5f71\u54cdspike\u86cb\u767d\u7684\u6784\u8c61\u504f\u597d\uff08\u56fe5A\uff09\u3002\u540c\u65f6\uff0c\u5728\u201c\u5173\u95ed\u201d\u72b6\u6001\u7684spike+SPC-14\u4f53\u7cfb\u4e2d\u53d1\u73b0\u4e86\u591a\u4f59\u7684\u7535\u5b50\u4e91\u5bc6\u5ea6\uff0c\u6b64\u5bc6\u5ea6\u6b63\u597d\u4f4d\u4e8eFFA\u7ed3\u5408\u4f4d\u70b9\u5e76\u4e14SPC-14\u7684\u5206\u5b50\u7ed3\u6784\u80fd\u591f\u5f88\u597d\u7684\u4e0e\u5176\u5951\u5408\uff08\u56fe5B\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22005.png\"><img loading=\"lazy\" width=\"1024\" height=\"736\" src=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22005-1024x736.png\" alt=\"\" class=\"wp-image-1208\" srcset=\"https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22005-1024x736.png 1024w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22005-300x216.png 300w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22005-768x552.png 768w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2023\/02\/22005.png 1269w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<p><strong>\u56fe<\/strong><strong>5<\/strong>\uff08A\uff09spike\u86cb\u767d\u5728\u6709\u65e0SPC-14\u52a0\u5165\u4e0b\u7684\u51b7\u51bb\u7535\u955c\u5bc6\u5ea6\u56fe\u3002\uff08B\uff09spike\u86cb\u767d\u4e0eSPC-14\u590d\u5408\u7269\u7684\u7535\u955c\u7ed3\u6784\u3002<\/p>\n\n\n\n<ul><li>\u201c\u8def\u6f2b\u6f2b\u5176\u4fee\u8fdc\u516e\u201d 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rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1021\/acscentsci.2c01190\" target=\"_blank\">\u8bba\u6587\u94fe\u63a5<\/a>  <\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>ACS Central Science | \u4ee5\u4e0d\u53d8\u5e94\u4e07\u53d8\uff1a\u9ec4\u725b\u5b9e\u9a8c\u5ba4\u5229\u7528\u865a\u62df\u7b5b\u9009\u65b9\u6cd5\u53d1\u73b0\u53ef\u8c03\u63a7\u65b0\u51a0\u75c5\u6bd2\u523a\u7a81\u86cb\u767d\u6784\u8c61\u8f6c\u53d8\u7684\u5c0f\u5206\u5b50\u8c03\u8282\u5242 \u5bfc\u8bfb\uff1a \u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\uff08SARS-CoV-2\uff09\u5229\u7528\u5176\u5305\u819c\u4e0a\u7684\u4e09\u805a\u4f53\u523a\u7a81\uff08spike\uff09\u86cb\u767d\u4e0e\u5bbf\u4e3b\u7ec6\u80deACE2\u53d7\u4f53\u7ed3\u5408\u4ee5\u4ecb\u5bfc\u75c5\u6bd2\u7684\u5165\u4fb5\uff08\u89c6\u98911\uff09\u3002\u7531\u4e8e\u5728\u611f\u67d3\u8fc7\u7a0b\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\uff0cspike\u86cb\u767d\u662f\u75ab\u82d7\u548c\u6297\u4f53\u836f\u7269\u7814\u53d1\u7684\u4e3b\u8981\u9776\u6807\u3002\u5c3d\u7ba1\u56fd\u5185\u5916\u5df2\u6709\u9488\u5bf9spike\u86cb\u767d\u7684\u6279\u51c6\u6216\u7d27\u6025\u4f7f\u7528\u6388\u6743\u7684\u75ab\u82d7\u3001\u6297\u4f53\u836f\u7269\u7528\u4e8e\u4e34\u5e8a\uff0c\u4f46\u968f\u7740\u53d8\u5f02\u682a\u7684\u4e0d\u65ad\u51fa\u73b0\u53ca\u6d41\u884c\uff0c\u5c24\u5176\u662fspike\u86cb\u767d\u6210\u4e3a\u7a81\u53d8\u70ed\u70b9\uff0c\u5bf9\u75ab\u82d7\u7684\u4fdd\u62a4\u7387\u548c\u6297\u4f53\u836f\u7269\u7684\u6cbb\u7597\u6548\u679c\u63d0\u51fa\u4e86\u4e25\u5cfb\u7684\u6311\u6218\u3002\u76f8\u6bd4\u6297\u4f53\u836f\u7269\u800c\u8a00\uff0c\u5c0f\u5206\u5b50\u836f\u7269\u5177\u6709\u5bf9\u7a81\u53d8\u4e0d\u654f\u611f\u3001\u53ef\u53e3\u670d\u7ed9\u836f\u3001\u751f\u4ea7\u8fd0\u8f93\u6210\u672c\u4f4e\u7b49\u6f5c\u529b\uff0c\u662f\u4e00\u79cd\u6709\u524d\u666f\u7684\u65b0\u51a0\u75c5\u6bd2\u6cbb\u7597\u65b9\u6848\u3002\u76ee\u524d\u6ca1\u6709\u9488\u5bf9spike\u86cb\u767d\u7684\u5c0f\u5206\u5b50\u5019\u9009\u5316\u5408\u7269\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\uff0c\u591a\u89d2\u5ea6\u5f00\u53d1\u65b0\u51a0\u75c5\u6bd2\u7684\u65b0\u578b\u9884\u9632\u548c\u6cbb\u7597\u836f\u7269\u4ecd\u523b\u4e0d\u5bb9\u7f13\u3002 \u89c6\u98911 \u878d\u5408\u524dspike\u86cb\u767d\u7684\u4e24\u79cd\u6784\u8c61\u72b6\u6001 \u8fd9\u4e09\u5e74\u6765\uff0c\u8086\u8650\u5168\u7403\u7684\u65b0\u51a0\u75c5\u6bd2\u53d8\u5316\u591a\u7aef\uff0c\u4ece\u539f\u59cb\u682a\u5f00\u59cb\uff0c\u6f14\u5316\u51fa\u963f\u5c14\u6cd5\u3001\u8d1d\u5854\u3001\u4f3d\u9a6c\u3001\u5fb7\u5c14\u5854\uff0c\u76f4\u5230\u73b0\u5728\u5965\u5bc6\u514b\u620e\u53c8\u6210\u4e3a\u6700\u6d41\u884c\u6bd2\u682a\uff0c\u8fd8\u5206\u5316\u51fa\u4e0d\u540c\u4e9a\u578b\uff0c\u81f3\u4e8e\u5c06\u6765\u5982\u4f55\u53d8\u5e7b\uff0c\u96be\u4ee5\u9884\u6599\u3002\u4f46\u4e07\u53d8\u4e0d\u79bb\u5176\u5b97\uff0c\u65b0\u51a0\u75c5\u6bd2\u518d\u53d8\u5e7b\u65e0\u7a77\uff0c\u4e5f\u4ecd\u7136\u9075\u5faa\u75c5\u6bd2\u7684\u751f\u6d3b\u53f2\uff0c\u9075\u5faa\u5438\u9644\u3001\u8fdb\u5165\u3001\u8131\u58f3\u3001\u590d\u5236\u3001\u6210\u719f\u548c\u91ca\u653e\u7684\u751f\u547d\u5468\u671f\u3002\u9488\u5bf9\u65b0\u51a0\u75c5\u6bd2\u8fdb\u884c\u7684\u65b0\u836f\u7814\u53d1\u4e5f\u662f\u56f4\u7ed5\u7740\u8fd9\u51e0\u4e2a\u5173\u952e\u8282\u70b9\u8fdb\u884c\u3002\u6291\u5236\u5df2\u5165\u4fb5\u7ec6\u80de\u7684\u75c5\u6bd2\u590d\u5236\u5df2\u6709\u591a\u4e2a\u5c0f\u5206\u5b50\u836f\u7269\u6279\u51c6\u4e0a\u5e02\u6216\u8005\u7d27\u6025\u4f7f\u7528\u6388\u6743\uff0c\u59823CL\u86cb\u767d\u9176\u6291\u5236\u5242Paxlovid\u548cEnsitrelvir\uff0c\u5982RdRp\u6291\u5236\u5242Remdesivir\u548cMolnupiravir\u3002\u4f46\u76f4\u63a5\u963b\u65ad\u65b0\u51a0\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\u7684\u9014\u5f84\uff0c\u5c1a\u672a\u6709\u4e00\u6b3e\u5c0f\u5206\u5b50\u836f\u7269\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\uff0c\u867d\u7136\u8fd9\u6761\u9014\u5f84\u5df2\u7ecf\u88ab\u6297\u4f53\u548c\u75ab\u82d7\u9a8c\u8bc1\u4e86\u5176\u53ef\u884c\u6027\uff0c\u4f46\u8fd9\u7c7b\u751f\u7269\u836f\u5374\u7ecf\u5e38\u56e0\u4e3a\u65b0\u51a0\u75c5\u6bd2spike\u86cb\u767d\u53d8\u5f02\u800c\u5931\u6548\u30022020\u5e74Toelzer\u7b49\u4eba\u5728Science\u7b49\u6742\u5fd7\u8fde\u7eed\u53d1\u6587\uff0c\u53d1\u73b0spike\u86cb\u767d\u867d\u7136\u591a\u53d8\uff0c\u5374\u5177\u6709\u4e00\u4e2a\u975e\u5e38\u4fdd\u5b88\u7684\u6e38\u79bb\u8102\u80aa\u9178\uff08free fatty acid, FFA\uff09\u7ed3\u5408\u4f4d\u70b9\uff0c\u8c03\u63a7\u8be5\u4f4d\u70b9\u53ef\u4ee5\u6709\u6548\u5730\u6291\u5236\u75c5\u6bd2\u8fdb\u5165\u7ec6\u80de\uff0c\u79f0\u5176\u4e3a\u65b0\u51a0\u7684\u963f\u5580\u7409\u65af\u4e4b\u8e35\u3002\u53ef\u60dc\u7684\u662f\uff0c\u56e0\u4e3a\u5176\u7ed3\u5408\u4f4d\u70b9\u7684\u7279\u6b8a\u6027\uff0c\u53ea\u62a5\u9053\u8fc7\u51e0\u4e2a\u5076\u7136\u53d1\u73b0\u7684\u5929\u7136\u4ea7\u7269\uff0c\u5c1a\u672a\u627e\u5230\u53ef\u6210\u836f\u7684\u5c0f\u5206\u5b50\u3002 \u90a3\u4e48\uff0c\u9762\u5bf9\u65b0\u51a0\u591a\u53d8\u7684spike\u86cb\u767d\uff0c\u4ee5\u4e0d\u53d8\u5e94\u4e07\u53d8\uff0c\u662f\u5426\u53ef\u4ee5\u901a\u8fc7\u57fa\u4e8e\u7ed3\u6784\u7684\u865a\u62df\u7b5b\u9009\uff0c\u7cbe\u786e\u5730\u9776\u5411\u65b0\u51a0\u75c5\u6bd2\u7684\u4e03\u5bf8\u2014\u2014\u6e38\u79bb\u8102\u80aa\u9178\u7ed3\u5408\u4f4d\u70b9\u2014\u2014\u5c04\u51fa\u8fd9\u4e00\u7bad\uff1f 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