{"id":1126,"date":"2022-07-10T16:48:20","date_gmt":"2022-07-10T08:48:20","guid":{"rendered":"https:\/\/www.huanglab.org.cn\/wordpress\/?p=1126"},"modified":"2022-07-11T09:56:15","modified_gmt":"2022-07-11T01:56:15","slug":"%e4%b8%8eace2%e5%8f%97%e4%bd%93%e7%bb%93%e5%90%88%e6%9b%b4%e5%bc%ba%e7%9a%84%e6%96%b0%e5%9e%8b%e5%86%a0%e7%8a%b6%e7%97%85%e6%af%92%e5%a5%a5%e5%af%86%e5%85%8b%e6%88%8e%e5%8f%98%e5%bc%82%e6%a0%aaba-2","status":"publish","type":"post","link":"https:\/\/www.huanglab.org.cn\/wordpress\/?p=1126","title":{"rendered":"\u4e0eACE2\u53d7\u4f53\u7ed3\u5408\u66f4\u5f3a\u7684\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u5965\u5bc6\u514b\u620e\u53d8\u5f02\u682aBA.2 \u548c BA.1.1\u7684\u7ed3\u6784\u57fa\u7840\u7814\u7a76"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2022\/07\/ace.jpg\"><img loading=\"lazy\" src=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2022\/07\/ace.jpg\" alt=\"\" class=\"wp-image-1128\" width=\"257\" height=\"257\" srcset=\"https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2022\/07\/ace.jpg 375w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2022\/07\/ace-300x300.jpg 300w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2022\/07\/ace-150x150.jpg 150w\" sizes=\"(max-width: 257px) 100vw, 257px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><a href=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2022\/07\/wq.jpg\"><img loading=\"lazy\" src=\"http:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2022\/07\/wq-768x1024.jpg\" alt=\"\" class=\"wp-image-1127\" width=\"252\" height=\"335\" srcset=\"https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2022\/07\/wq-768x1024.jpg 768w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2022\/07\/wq-225x300.jpg 225w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2022\/07\/wq-1152x1536.jpg 1152w, https:\/\/www.huanglab.org.cn\/wordpress\/wp-content\/uploads\/2022\/07\/wq.jpg 1279w\" sizes=\"(max-width: 252px) 100vw, 252px\" \/><\/a><figcaption>Qing Wang<\/figcaption><\/figure>\n\n\n\n<p>\u3000\u3000\u76ee\u524d\u6d41\u884c\u7684 Omicron \u53d8\u4f53\u662f\u5df2\u77e5\u7a81\u53d8\u6570\u91cf\u6700\u591a\u7684 SARS-CoV-2 \u6bd2\u682a\u3002 \u7edf\u8ba1\u5206\u6790\u8868\u660e\uff0cBA.2\u7684\u6709\u6548\u7e41\u6b96\u6570\u662fBA.1\u76841.4\u500d\u3002BA.2 \u7684\u751f\u957f\u4f18\u52bf\u88ab\u8ba4\u4e3a\u4e0e\u5176\u8f83\u9ad8\u7684\u514d\u75ab\u9003\u9038\u80fd\u529b\u6709\u5173\u3002\u7136\u800c\uff0c\u5728\u63a5\u53d7\u75ab\u82d7\u63a5\u79cd\u6216\u7ecf\u5386\u8fc7 SARS CoV-2 \u611f\u67d3\u7684\u4e2a\u4f53\u4e2d\uff0c\u9488\u5bf9 BA.1 \u548c BA.2 \u7684\u4e2d\u548c\u6297\u4f53\u6c34\u5e73\u5dee\u5f02\u5f88\u5c0f\uff0c\u56e0\u6b64\u5f88\u96be\u89e3\u91ca BA.2 \u7684\u4f20\u64ad\u7387\u9ad8\u4e8e BA.1\u30022022\u5e746\u670815\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5fae\u751f\u7269\u7814\u7a76\u6240\u9ad8\u798f\uff0c\u8d75\u6b23\uff0c\u5b59\u4e1a\u5e73\u53ca\u5317\u4eac\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u9ec4\u725b\u5171\u540c\u901a\u8baf\u5728Cell \u5728\u7ebf\u53d1\u8868\u9898\u4e3a\u201cStructural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1\u201d\u7684\u7814\u7a76\u8bba\u6587\uff0c\u8be5\u7814\u7a76\u53d1\u73b0\u4eba\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u6362\u9176 2 (hACE2) \u4e0e\u56db\u4e2a\u65e9\u671f Omicron \u4e9a\u53d8\u4f53\uff08BA.1\u3001BA.1.1\u3001BA.2 \u548c BA.3\uff09\u7684\u53d7\u4f53\u7ed3\u5408\u57df (RBD) \u7684\u7ed3\u5408\u4eb2\u548c\u529b\u987a\u5e8f\u4e3a BA.1.1&gt;BA.2&gt;BA.3\u2248BA.1\u3002 hACE2 \u4e0e BA.1.1\u3001BA.2 \u548c BA.3 \u7684 RBD \u7684\u590d\u6742\u7ed3\u6784\u8868\u660e BA.2 \u6bd4 BA.1 \u66f4\u9ad8\u7684 hACE2 \u7ed3\u5408\u4eb2\u548c\u529b\u4e0e BA.2 \u4e2d\u4e0d\u5b58\u5728 G496S \u7a81\u53d8\u6709\u5173\u3002BA.1.1 \u4e2d\u7684 R346K \u7a81\u53d8\u4e3b\u8981\u901a\u8fc7\u957f\u7a0b\u6539\u53d8\u5f71\u54cd BA.1.1 RBD\/hACE2 \u754c\u9762\u4e2d\u7684\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\uff0c\u5e76\u5bfc\u81f4 BA.1.1 RBD \u7684 hACE2 \u4eb2\u548c\u529b\u9ad8\u4e8e BA.1 RBD\u3002\u8fd9\u4e9b\u7ed3\u679c\u63ed\u793a\u4e86 BA.1.1\u3001BA.2 \u548c BA.3 RBD \u4e4b\u95f4\u4e0d\u540c\u7684 hACE2 \u7ed3\u5408\u6a21\u5f0f\u7684\u7ed3\u6784\u57fa\u7840\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867422007280?via%3Dihub\" data-type=\"URL\" data-id=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867422007280?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">\u539f\u6587\u94fe\u63a5<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u3000\u76ee\u524d\u6d41\u884c\u7684 Omicron \u53d8\u4f53\u662f\u5df2\u77e5\u7a81\u53d8\u6570\u91cf\u6700\u591a\u7684 SARS-CoV-2 \u6bd2\u682a\u3002 \u7edf\u8ba1\u5206\u6790\u8868\u660e\uff0cBA.2\u7684\u6709\u6548\u7e41\u6b96\u6570\u662fBA.1\u76841.4\u500d\u3002BA.2 \u7684\u751f\u957f\u4f18\u52bf\u88ab\u8ba4\u4e3a\u4e0e\u5176\u8f83\u9ad8\u7684\u514d\u75ab\u9003\u9038\u80fd\u529b\u6709\u5173\u3002\u7136\u800c\uff0c\u5728\u63a5\u53d7\u75ab\u82d7\u63a5\u79cd\u6216\u7ecf\u5386\u8fc7 SARS CoV-2 \u611f\u67d3\u7684\u4e2a\u4f53\u4e2d\uff0c\u9488\u5bf9 BA.1 \u548c BA.2 \u7684\u4e2d\u548c\u6297\u4f53\u6c34\u5e73\u5dee\u5f02\u5f88\u5c0f\uff0c\u56e0\u6b64\u5f88\u96be\u89e3\u91ca BA.2 \u7684\u4f20\u64ad\u7387\u9ad8\u4e8e BA.1\u30022022\u5e746\u670815\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5fae\u751f\u7269\u7814\u7a76\u6240\u9ad8\u798f\uff0c\u8d75\u6b23\uff0c\u5b59\u4e1a\u5e73\u53ca\u5317\u4eac\u751f\u547d\u79d1\u5b66\u7814\u7a76\u6240\u9ec4\u725b\u5171\u540c\u901a\u8baf\u5728Cell \u5728\u7ebf\u53d1\u8868\u9898\u4e3a\u201cStructural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1\u201d\u7684\u7814\u7a76\u8bba\u6587\uff0c\u8be5\u7814\u7a76\u53d1\u73b0\u4eba\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u6362\u9176 2 (hACE2) \u4e0e\u56db\u4e2a\u65e9\u671f Omicron \u4e9a\u53d8\u4f53\uff08BA.1\u3001BA.1.1\u3001BA.2 \u548c BA.3\uff09\u7684\u53d7\u4f53\u7ed3\u5408\u57df (RBD) \u7684\u7ed3\u5408\u4eb2\u548c\u529b\u987a\u5e8f\u4e3a BA.1.1&gt;BA.2&gt;BA.3\u2248BA.1\u3002 hACE2 \u4e0e BA.1.1\u3001BA.2 \u548c BA.3 \u7684 RBD \u7684\u590d\u6742\u7ed3\u6784\u8868\u660e BA.2 \u6bd4 BA.1 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0},"categories":[],"tags":[],"_links":{"self":[{"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1126"}],"collection":[{"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1126"}],"version-history":[{"count":4,"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1126\/revisions"}],"predecessor-version":[{"id":1141,"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1126\/revisions\/1141"}],"wp:attachment":[{"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1126"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1126"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.huanglab.org.cn\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}